Human 5-HT7 APC-conjugated Antibody

Catalog #: FAB10325A Datasheet / COA / SDS

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FAB10325A-100

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Detection of 5-HT7 in 5-HT7 HEK293/eGFP transfecants vs Irrelevant HEK293/eGFP transfecants by Flow Cytometry

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All 5-HT7 Antibodies

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Human 5-HT7 APC-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human 5-HTR7 in direct ELISAs.

Source

Monoclonal Mouse IgG_2B Clone # 1015322

Purification

Protein A or G purified from cell culture supernatant

Immunogen

Synthetic peptide containing human 5-HTR7
Accession # P34969

Formulation

Supplied in a saline solution containing Tris, NaCl and Sodium Azide.

Label

Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)

Applications

Recommended Concentration

Sample

Flow Cytometry

Immunohistochemistry

CyTOF-ready

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry

5-HT7 Antibody (1015322) [Allophycocyanin]

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Detection of 5-HT7 in 5-HT7 HEK293/eGFP transfecants vs Irrelevant HEK293/eGFP transfecants by Flow Cytometry 5-HT7 HEK293/eGFP transfecants (A) vs Irrelevant HEK293/eGFP transfecants (B) were stained with Mouse Anti-Human 5-HT7 APC‑conjugated Monoclonal Antibody (Catalog # FAB10325A). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.

12 months from date of receipt, 2 to 8 °C as supplied.

Background: 5-HT7

HTR2B is a G-protein coupled receptor for serotonin. The 5HT2 receptors mediate many of the central and peripheral physiologic functions of serotonin. 5HT2B plays a role in the regulation of dopamine and serotonin release, serotonin uptake and in the regulation of extracellular dopamine and serotonin levels. It also plays a role in pulmonary vasoconstriction and regulating cardiac structure and functions. 5HT2B receptors were shown to be expressed in human failing heart and have been strongly implicated in drug induced valvular heart disease.

Long Name

5-Hydroxytryptamine Receptor 7

Entrez Gene IDs

3363 (Human); 15566 (Mouse); 65032 (Rat)

Alternate Names

5HT7; 5-HT7; 5-HT-7; 5-HT75-hydroxytryptamine receptor 7; 5-HT-X; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); HTR7; serotonin 5-HT-7 receptor; Serotonin receptor 7