Human c-Maf Alexa Fluor® 750-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: c-Maf

c-Maf is an approximately 40 kDa transcriptional regulator that contains one bZIP domain. It can associate into homodimers and heterodimers with other basic leucine zipper transcription factors. c-Maf plays an important role in fetal erythropoiesis, lens development, mechanosensory neuron development, and the differentiation of chondrocytes and osteoblasts. In the pancreas, c-Maf promotes the transcription of glucagon in alpha cells and insulin in beta cells. In immune cells, it controls Th17 and Treg differentiation by regulating the transcription of IL-4, IL-12 p35, IL-21, IL-22, and GM-CSF. Human c-Maf shares 97% amino acid sequence identity with mouse and rat c-Maf. Alternative splicing of human c-Maf generates a long isoform with a 30 aa substitution for the C-terminal methionine.

Product Datasheets

Related Research Areas

• Apoptosis Transcription Factors and Regulators
• Basic Helix-Loop-Helix (bHLH) Transcription Factors
• Basic Leucine Zipper (bZIP) Transcription Factors
• Cancer Biomarkers
• Cancer Stem Cell Markers
• Cancer Stem Cell Transcription Factors
• DNA Damage and Repair
• Embryonic and Induced Pluripotent Stem Cell Markers
• Epithelial Stem Cell Transcription Factors
• Hematopoietic Stem Cell Transcription Factors and Regulators
• Natural Killer T (NKT) Cells
• Pluripotent Stem Cell Transcription Factors
• Transcription Factors in the Akt Pathway