Human DOK7 Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB6398V Datasheet / COA / SDS

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FAB6398V-100UG

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Human DOK7 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human DOK7 in direct ELISAs.

Source

Monoclonal Mouse IgG2a Clone # 651601

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human DOK7
Ala179-Pro299
Accession # Q18PE1

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: DOK7

DOK7 (Downstream of kinase 7) is a 55 kDa member of the DOK family of cytoplasmic adaptor proteins. It links the acetylcholine receptor and the receptor tyrosine kinase MuSK in skeletal and cardiac muscle. Mutations can cause familial myasthenic syndromes. The 504 amino acid (aa) human DOK7 contains pleckstrin homology (aa 7-109) and phosphotyrosine-binding (PTK, aa 125-236) and SH2 domains, and a C-terminal nuclear export signal. Splicing isoforms of 255, 608 and 366 aa diverge at aa 175 or 500, or have 40 divergent aa replacing aa 1-178, respectively. Within aa 179-299, human DOK7 shares 92% and 93% aa identity with mouse and rat DOK7, respectively.

Long Name

Downstream of Tyrosine Kinase 7

Entrez Gene IDs

285489 (Human); 231134 (Mouse); 305448 (Rat)

Alternate Names

C4orf25; C4orf25chromosome 4 open reading frame 25; CMS1B; docking protein 7; DOK7; Dok-7; Downstream of tyrosine kinase 7; FLJ33718; FLJ39137; FLJ90556; protein Dok-7