Human Endothelin-3 Alexa Fluor® 488-conjugated Antibody

Catalog #: FAB5579G Datasheet / COA / SDS

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FAB5579G-100UG

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All Endothelin-3 Antibodies

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Human Endothelin-3 Alexa Fluor® 488-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Endothelin‑3.

Source

Monoclonal Mouse IgG1 Clone # 3B6

Purification

Protein A or G purified

Immunogen

Human Endothelin-3 synthetic peptide
Accession # P14138

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 488 (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration

Sample

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Endothelin-3

Endothelin-1, -2, and -3 are encoded by three separate genes as prepropolypeptides that are cleaved to yield the secreted and inactive big endothelins. Big
Endothelin-3 is further cleaved by Kell blood group antigen endopeptidases to generate the 21 amino acid (aa) bioactive mature peptide. It interacts primarily with the 7TM receptor EDNRB to induce a variety of effects including bronchoconstriction, arteriolar vasoconstriction, gall bladder contraction, insulin and norepinephrine release, and the maintenance and development of melanocytes and neural crest progenitors. Mature human Endothelin-3 shares 100% aa sequence identity with mouse and rat Endothelin-3.

Entrez Gene IDs

1908 (Human); 13616 (Mouse); 366270 (Rat)

Alternate Names

EDN3; endothelin 3; Endothelin3; Endothelin-3; ET3; ET-3; HSCR4; MGC15067; MGC61498; PPET3; preproendothelin-3; truncated endothelin 3; WS4B