Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Allophycocyanin (Excitation = 620-650 nm, Emission = 660-670 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # 672505
View all FCRL6/FcRH6 Primary Antibodies »

Product Specifications

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant human FCRL6/FcRH6      
Lys16-Leu312
Accession # Q6DN72

Specificity

Detects human FCRL6/FcRH6 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) FCRL1, rhFCRL2, rhFCRL3, rhFCRL4, rhFCRL5, rhFcRN, or rhFCRLB/FCRY is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Human FCRL6/FcRH6 APC‑conjugated Antibody

Detection of FCRL6/FcRH6 antibody in Human Blood Lymphocytes antibody by Flow Cytometry.

Detection of FCRL6/FcRH6 in Human Blood Lymphocytes by Flow Cytometry.

Human peripheral blood lymphocytes were stained with Mouse Anti-Human NCAM-1/CD56 PE-conjugated Monoclonal Antibody (Catalog # FAB2408P) and either (A) Mouse Anti-Human FCRL6/FcRH6 APC-conjugated Monoclonal Antibody (Catalog # FAB6745A) or (B) Mouse IgG1Allophycocyanin Isotype Control (Catalog # IC002A). View our protocol for Staining Membrane-associated Proteins.

Applications for Human FCRL6/FcRH6 APC‑conjugated Antibody

Application
Recommended Usage

Flow Cytometry

10 µL/106 cells
Sample: Human peripheral blood lymphocytes

Spectra Viewer

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: FCRL6/FcRH6

FCRL6 (Fc receptor-like protein 6; also FcRH6 and IFGP6) is a 66 kDa member of the Ig Superfamily.  It is found on CD56dim CD16+ NK cells, CD56+ CD3+ NKT cells, gd T cells, and effector plus effector-memory CD8+ T cells.  FCRL6 is not a receptor for immunoglobulin.  It does, however, bind to isoforms of HLA-DR that are expressed on APCs.  Given that FCRL6 contains a cytoplasmic ITIM, FCRL6 may function as an inhibitory receptor for MHC Class II.  Mature human FCRL6 is a 415 amino acid (aa) type I transmembrane protein.  It contains a 288 aa extracellular region (aa 20-307) that shows three C2-type Ig-like domains (aa 20-293), and a 106 aa cytoplasmic domain.  There are multiple potential splice variants.  One shows a deletion of aa 105-200 accompanied by a 13 aa substitution for aa 394-434; a second possesses a 15 aa substitution for aa 383-434; and a third shows an alternative start site seven aa upstream of the standard site accompanied by a 13 aa substitution for aa 394-434.  Over aa 16-312, human FCRL6 shares only 33% aa identity with the mouse counterpart to FCRL6.

Long Name

Fc Receptor-like 6

Alternate Names

FcRH6, IFGP6

Entrez Gene IDs

343413 (Human); 677296 (Mouse)

Gene Symbol

FCRL6

UniProt

Q6DN72 (Human)

Additional FCRL6/FcRH6 Products

Product Documents for Human FCRL6/FcRH6 APC‑conjugated Antibody

Certificate of Analysis

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Product Specific Notices for Human FCRL6/FcRH6 APC‑conjugated Antibody

For research use only

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