Human Matrilin-1 Alexa Fluor® 488-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Matrilin-1

Matrilin-1, also known as Cartilage Matrix Protein (CMP) is a 50-60 kDa extracellular matrix protein that belongs to the superfamily of von Willebrand factor A (VWA) containing proteins. It is primarily expressed in cartilage and functions as a bridging component between proteins of the collagenous matrix. Mature human Matrilin-1 contains two VWA domains that flank one EGF-like repeat, followed by a C-terminal coiled coil domain. The Matrilins differ in the number of VWA domains (one or two) and EGF-like repeats (one, three, four, or ten) they contain. Human Matrilin-1 shares 91% aa sequence identity with human and rat Matrilin-1. The coiled coil domain of Matrilin-1 mediates disulfide-linked homo-trimer formation. It can also assemble into hetero-oligomers with Matrilin-2, -3, and -4.

Product Datasheets

Related Research Areas

• Chondrogenesis Markers
• Extracellular Matrix and Related Molecules
• Extracellular Matrix Molecules