Human PDZD2 Alexa Fluor® 350-conjugated Antibody

Catalog #: FAB7670U Datasheet / COA / SDS

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FAB7670U-100UG

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Human PDZD2 Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human PDZD2 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse PDZD2 is observed.

Source

Monoclonal Mouse IgG2a Clone # 787924

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human PDZD2
Ser2489-Ser2839
Accession # O15018

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PDZD2

PDZD2 (PSD95, Discs-large and ZO-1 domain-containing protein 2), also called AIPC (activated in prostate cancer) and PDZK3, is a multi-PDZ-domain protein that is ubiquitously expressed. The 2839 amino acid (aa) human PDZD2 is found in the endoplasmic reticulum. Caspase cleavage produces the 347 aa, 37 kDa secreted mature form (aa 2493-2839). A 2640 aa isoform is lacking 199 aa N-terminal to the mature sequence. The processed, mature form contains two PDZ domains which interact with the C-terminus of partner proteins, promotes maturation of pancreatic b cells, and is highly expressed in human prostate tumors. Human PDZD2 shares 72% aa sequence identity with mouse or rat PDZD2.

Long Name

PDZ Domain Containing 2

Entrez Gene IDs

23037 (Human); 68070 (Mouse); 65034 (Rat)

Alternate Names

Activated in prostate cancer protein; AIPC; AIPCPAPIN; KIAA0300; KIAA0300PDZ domain-containing protein 3; Papin; PDZ domain containing 2; PDZ domain containing 3; PDZ domain-containing protein 2; PDZD2; PDZK3; Pin1