Paired immunoglobulin-like, type 2 receptor beta (PILR-beta ) is a type I transmembrane (TM) glycoprotein belonging to the Ig superfamily. It is the activating counterpart to the ITIM-bearing PILR-alpha inhibitory receptor. PILR-beta is expressed in a wide variety of hematopoietic cells, including NK cells, macrophages, dendritic cells and neutrophils. Mature human PILR-beta is a 208 amino acid (aa) protein with one V-type Ig-like extracellular domain, a truncated cytoplasmic tail, and a positively-charged residues in its TM domain that interacts with ITAM‑bearing adaptor molecules. Over aa 20-189, in their ECD, human PILR-beta and PILR-alpha share 82% aa sequence identity. The aa sequence of mouse PILR-beta ECD is only 43% identical to that of human PILR-beta ECD.
Human PILR‑ beta PE‑conjugated Antibody
R&D Systems | Catalog # FAB4189P
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Immunogen
Gln20-Ala189
Accession # Q9UKJ0
Specificity
Clonality
Host
Isotype
Scientific Data Images for Human PILR‑ beta PE‑conjugated Antibody
Detection of PILR‑ beta in Human Peripheral Blood Granulocytes by Flow Cytometry.
Human peripheral blood granulocytes were stained with Sheep Anti-Human PILR-beta PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB4189P, filled histogram) or isotype control antibody (Catalog # IC016P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Applications for Human PILR‑ beta PE‑conjugated Antibody
Flow Cytometry
Sample: Human peripheral blood granulocytes
Spectra Viewer
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
Spectra Viewer
Flow Cytometry Panel Builder
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Advanced Features
- Spectra Viewer - Custom analysis of spectra from multiple fluorochromes
- Spillover Popups - Visualize the spectra of individual fluorochromes
- Antigen Density Selector - Match fluorochrome brightness with antigen density
Formulation, Preparation, and Storage
Purification
Formulation
Shipping
Stability & Storage
Background: PILR-beta
Long Name
Alternate Names
Gene Symbol
UniProt
Additional PILR-beta Products
Product Documents for Human PILR‑ beta PE‑conjugated Antibody
Product Specific Notices for Human PILR‑ beta PE‑conjugated Antibody
For research use only
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Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
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- View all Protocols, Troubleshooting, Illustrated assays and Webinars