Human PPAR alpha /NR1C1 Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB24781V Datasheet / COA / SDS

Recombinant Monoclonal Antibody

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FAB24781V-100UG

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Human PPAR alpha /NR1C1 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human PPAR alpha /NR1C1 in direct ELISAs.

Source

Monoclonal Rabbit IgG Clone # 2297B

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human PPARÎ±/NR1C1
Met1-Asn99
Accession # Q07869

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PPAR alpha/NR1C1

Peroxisome proliferator activated receptor alpha (PPARA) a member of the steroid hormone receptor superfamily, is a nuclear transcription factor which mediates the activity of peroxisome proliferators. PPAR alpha exhibits the highest affinity with unsaturated fatty acids, and linolenic acids. PPAR alpha is expressed in brown fat, liver, kidney, heart, mucosa of the stomach and duodenum, retina, adrenal gland, skeletal muscle, pancreatic islets and smooth muscle cells. PPAR alpha plays important roles in lipid and glucose metabolism, and has been implicated in obesity-related metabolic diseases such as hyperlipidemia, insulin resistance, and coronary artery disease.

Long Name

Peroxisome Proliferator-activated Receptor alpha

Entrez Gene IDs

5465 (Human)

Alternate Names

alpha; hPPAR; NR1C1; NR1C1MGC2237; Nuclear receptor subfamily 1 group C member 1; peroxisome proliferator-activated receptor alpha; PPAR alpha; PPARA; PPARalpha; PPAR-alpha; PPARMGC2452