Human RARRES3 Alexa Fluor® 488-conjugated Antibody

Catalog #: FAB6139G Datasheet / COA / SDS

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FAB6139G-100UG

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Human RARRES3 Alexa Fluor® 488-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Recognizes human RARRES3 in Western blots and direct ELISAs. In Western blots and direct ELISAs, no cross-reactivity with recombinant human (rh) RARRES1 or rhLatexin is observed.

Source

Monoclonal Mouse IgG2b Clone # 659209

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human RARRES3
Asp12-Lys134
Accession # Q9UL19

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 488 (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration

Sample

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: RARRES3

RARRES3 (retinoic acid receptor responder 3), also called Tig3 (tazarotene-induced gene 3) or RIG1 (retinoid-inducible gene 1), is an 18 kDa, 164 amino acid (aa) cytoplasmic protein within the LRAT (lecithin retinol acyltransferase) family of growth inhibitory proteins, which are class II tumor-suppressors. RARRES3 is expressed in a variety of cells including epidermal keratinocytes, and may be downregulated in tumor cells and cell lines. It shows phospholipase activity and interaction with type I transglutaminase. A C-terminal hydrophobic region allows perinuclear localization. RARRES3 is not structurally related to other RARRES genes. A canine ortholog shares 72% aa identity within the region used as an immunogen; orthologs are unlikely in rodents.

Long Name

Retinoic Acid Receptor Responder [Tazarotene-induced] 3

Entrez Gene IDs

5920 (Human)

Alternate Names

HRASLS4; PLA1/2-3; RARRES3; RAR-responsive protein TIG3; retinoic acid receptor responder (tazarotene induced) 3; retinoic acid receptor responder protein 3; retinoic acid-inducible gene 1; Retinoid-inducible gene 1 protein; RIG1; Tazarotene-induced gene 3 protein; TIG3; TIG3MGC8906