Human ZNF143 Alexa Fluor® 350-conjugated Antibody

Catalog #: FAB6804U Datasheet / COA / SDS

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FAB6804U-100UG

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Human ZNF143 Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human ZNF143 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) ZNF24, rhZNF206, rhZNF281, rhDC-SCRIPT/ZNF366, rhZNF423, or recombinant mouse Bcl-6 is observed.

Source

Monoclonal Mouse IgG1 Clone # 677314

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human ZNF143
Gly459-Asp638
Accession # P52747

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: ZNF143

ZNF143 is a 69 kDa (unglycosylated) member of the GLI C2H2-type zinc-finger protein family. Human ZNF143 is 638 amino acids (aa) in length. A second isoform is produced from the deletion of residues 39-69. The protein contains seven C2H2-type zinc fingers, and is expressed in all tissues tested with greatest expression in the ovary. Functionally, ZNF143 serves as a transcriptional activator. Its other functions include acting as an activator for the gene for selenocysteine tRNA (tRNAsec), binding to the SPH motif of small nuclear RNA (snRNA) gene promoters, and participating in efficient U6 RNA polymerase III transcription through its interaction with CHD8. Human ZNF143 shares 97% aa sequence identity with mouse ZNF143.

Long Name

Zinc Finger Protein 143

Entrez Gene IDs

7702 (Human); 20841 (Mouse); 361627 (Rat)

Alternate Names

hStaf; pHZ-1; SBF; SBFzinc finger protein 143 (clone pHZ-1); Selenocysteine tRNA gene transcription-activating factor; SPH-binding factor; STAF; STAFpHZ-1; transcriptional activator Staf; zinc finger protein 143; ZNF143