Key Product Details

Species Reactivity

Human

Applications

Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all IL-31 Primary Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 18 amino acid synthetic peptide from near the center of human IL-31. The immunogen is located within amino acids 60 - 110 of IL-31. Amino Acid Squence: CLSPDAQPPNNIHSPAIR

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Novus Biologicals Rabbit IL-31 Antibody - BSA Free (NBP1-76419) is a polyclonal antibody validated for use in WB, ELISA and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for IL-31 Antibody - BSA Free

Western Blot: IL-31 AntibodyBSA Free [NBP1-76419]

Western Blot: IL-31 AntibodyBSA Free [NBP1-76419]

Western Blot: IL-31 Antibody [NBP1-76419] - Human skeletal muscle tissue lysate with IL-31 antibody at (A) 2.5, (B) 5 and (C) 10 ug/ml.
IL-31 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: IL-31 Antibody - BSA Free [NBP1-76419] -

Immunocytochemistry/ Immunofluorescence: IL-31 Antibody - BSA Free [NBP1-76419] - Immunofluorescence of IL-31 in Human Skeletal Muscle cells with IL-31 antibody at 20 ug/mL.

Applications for IL-31 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/mL

Western Blot

2.5-10 ug/ml
Application Notes
Despite its predicted size, IL-31 runs at approximately 27 - 30 kDa in SDS-PAGE.

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IL-31

Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.

Long Name

Interleukin 31

Alternate Names

IL31

Gene Symbol

IL31

UniProt

AAS82846 (Mouse)

Additional IL-31 Products

Product Documents for IL-31 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for IL-31 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

IL-6 Family

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Protocols

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FAQs

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Associated Pathways

Th2 Differentiation Pathway Th2 Differentiation Pathway Thumbnail