Mouse FOLR4 Alexa Fluor® 488-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: FOLR4

FOLR4 (folate receptor 4; also FR4, FR‑δ and FOLBP‑3) is a 35 kDa glycoprotein member of the folate receptor family. It is found on mouse Treg cells, particularly those classified as natural and CD4⁺ CD25^- T cells that produce low amounts of IFN-gamma. Its function is unclear. Although folate family receptors can internalize folate, they are generally not the principal conduits for folate uptake. Mouse FOLR4 preproprecursor is 244 amino acids (aa) in length. It contains a 19 aa signal sequence plus a 225 aa proform. While there are no definitive structural motifs, there is presumably a C-terminal propeptide that gives rise to a GPI-linkage. There are three potential isoforms. One is 37 kDa in size and shows a 36 aa insertion after Glu155. Two others show a deletion of aa 47‑109, and a 17 aa substitution for aa 157‑244. Over aa 20‑100, mouse FOLR4 shares 84% and 70% aa identity with rat and human FOLR4, respectively.

Product Datasheets

Related Research Areas

• Cancer Biomarkers