Additional p53-related Compounds Small Molecules and Peptides

p53 (aka TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damage, hypoxia and spindle damage). Activation of p53 begins through a number of mechanisms including phosphorylation by ATM, ATR, Chk1 and MAPKs. MDM2 is a ubiquitin ligase that binds p53 and targets p53 for proteasomal degradation.

Phosphorylation, p14^ARF and USP7 prevent MDM2-p53 interactions, leading to an increase in stable p53 ...