ASK1 Inhibitors Small Molecules and Peptides

Apoptosis signal-regulated kinase 1 (ASK1) is a ubiquitously expressed serine/threonine kinase which induces apoptosis in a wide variety of cell types. ASK1 is a member of the MAP3K family and is therefore part of the MAPK signaling pathway. The kinase activates JNK and p38 through phosphorylation of SEK1/MKK7 and MKK3/MKK6 respectively, which induces mitochondria-dependent caspase activation and subsequent apoptosis. ASK1 is activated following auto-phosphorylation of Thr845 (mouse)/Thr838 ...