162 results for "CDK4" in 产品
CDK4 Products
Cyclin-dependent Kinase 4 (CDK4) is a 303 amino acid (aa) member of the Ser/Thr kinase family with a predicted molecular weight of 33.7 kDa. The human protein shares 94% and 95% aa sequence identity with the mouse and rat orthologs, respectively. CDK4 shuttles between the cytoplasm and nucleus as part of its role in cell cycle regulation. It promotes the transition from G1 to S phase by phosphorylating and inactivating RB1. Activation of CDK4 requires binding of a D-type Cyclin and ...
| Reactivity: | Human, Mouse, Rat, Bovine |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Simple Western |
![Immunocytochemistry/ Immunofluorescence: CDK4 Antibody [NBP1-31308]](https://resources.rndsystems.com/images/products/CDK4-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-31308-img0010.jpg "Immunocytochemistry/ Immunofluorescence: CDK4 Antibody [NBP1-31308]")
Protein kinase C inhibitor
| Alternate Names: | Gö 6850,Bisindolylmaleimide I |
| Chemical Name: | 2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide |
| Purity: | ≥98% |
| Reactivity: | Human, Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC/IF, Simple Western |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #6N3M6 |
| Applications: | IHC, WB |
![Western Blot: CDK4 Antibody (6N3M6) [NBP3-15344]](https://resources.rndsystems.com/images/products/CDK4-Antibody-3G7Q7-Western-Blot-NBP3-15344-img0008.jpg "Western Blot: CDK4 Antibody (6N3M6) [NBP3-15344]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #CL8102 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: CDK4 Antibody (CL8102) [NBP2-88912]](https://resources.rndsystems.com/images/products/CDK4-Antibody-CL8102-Western-Blot-NBP2-88912-img0007.jpg "Western Blot: CDK4 Antibody (CL8102) [NBP2-88912]")
Potent cdk4 and cdk6 inhibitor; brain penetrant
| Alternate Names: | Palbociclib |
| Chemical Name: | 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one isethionate salt |
| Purity: | ≥98% |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #4F11 |
| Applications: | WB, ELISA, ICC/IF, Mycoplasma |
![Western Blot: CDK4 Antibody (4F11) [H00001019-M03]](https://resources.rndsystems.com/images/products/CDK4-Antibody-4F11-Western-Blot-H00001019-M03-img0012.jpg "Western Blot: CDK4 Antibody (4F11) [H00001019-M03]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #CL8102 |
| Applications: | IHC, WB, ICC/IF |
![CDK4 Antibody (CL8102) - Azide and BSA Free Immunohistochemistry-Paraffin: CDK4 Antibody [NBP3-44220]](https://resources.rndsystems.com/images/products/nbp3-44220_mouse-cdk4-mab-cl8102-azide-and-bsa-free-28220251235181.jpg "Immunohistochemistry-Paraffin: CDK4 Antibody [NBP3-44220]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, IP |
![Western Blot: CDK4 Antibody [NBP2-32288]](https://resources.rndsystems.com/images/products/CDK4-Antibody-Western-Blot-NBP2-32288-img0018.jpg "Western Blot: CDK4 Antibody [NBP2-32288]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2A Monoclonal Clone #DCS-31 |
| Applications: | IHC, WB, ICC/IF, IP, MA |
![Western Blot: CDK4 Antibody (DCS-31) [NB120-6315]](https://resources.rndsystems.com/images/products/CDK4-Antibody-DCS-31-Western-Blot-NB120-6315-img0001.jpg "Western Blot: CDK4 Antibody (DCS-31) [NB120-6315]")
HMG-CoA reductase inhibitor
| Chemical Name: | (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate |
| Purity: | ≥98% |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 kappa Monoclonal Clone #2G7 |
| Applications: | WB, ELISA, ICC/IF |
![Western Blot: CDK4 Antibody (2G7) [H00001019-M04]](https://resources.rndsystems.com/images/products/CDK4-Antibody-2G7-Western-Blot-H00001019-M04-img0009.jpg "Western Blot: CDK4 Antibody (2G7) [H00001019-M04]")
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 kappa Monoclonal Clone #8A10 |
| Applications: | WB, ELISA, ICC/IF |
![Western Blot: CDK4 Antibody (8A10) [H00001019-M09]](https://resources.rndsystems.com/images/products/CDK4-Antibody-8A10-Western-Blot-H00001019-M09-img0010.jpg "Western Blot: CDK4 Antibody (8A10) [H00001019-M09]")
Potent HMG-CoA reductase inhibitor
| Alternate Names: | Mevinolin |
| Chemical Name: | (2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl-2-methyl butanoate |
| Purity: | ≥97% |
SETD8 inhibitor; also CDK4 inhibitor
| Chemical Name: | 2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione |
| Purity: | ≥98% |
Cdk inhibitor; potently inhibits cdk2 and cdk9
| Alternate Names: | L 86-8275 |
| Chemical Name: | 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride |
| Purity: | ≥98% |
Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9
| Chemical Name: | 4-[2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine |
| Purity: | ≥98% |
Potent and selective cdk inhibitor; orally bioavailable
| Chemical Name: | [4-Amino-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-5-pyrimidinyl](2,3-difluoro-6-methoxyphenyl)methanone |
| Purity: | ≥98% |
Selective Cdk4/6 Degrader (PROTAC®
| Chemical Name: | N-[4-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide |
| Purity: | ≥98% |
Dual cdk4/cdk6 inhibitor; orally bioavailable
| Alternate Names: | LEE-011 |
| Chemical Name: | 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide |
| Purity: | ≥98% |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #CDK4/8351R |
| Applications: | IHC |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #CDK4/8351R |
| Applications: | IHC |
CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader
| Chemical Name: | 4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-N-[[1-[4-[2-amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-3-butyn-1-yl]-1H-1,2,3-triazol-4-yl]methyl]-1-piperazineacetamide |
| Purity: | ≥95% |
Cyclin D1, CDK4/6 and cyclin D3 Degrader (PROTAC®)
| Chemical Name: | (2S,4R)-1-((S)-2-(7-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #23GB750 |
| Applications: | WB, Flow, ICC/IF, Mycoplasma |
