42 results for "Compounds for Induced Pluripotent Stem Cells Small Molecules and Peptides" in 产品

Compounds for Induced Pluripotent Stem Cells Small Molecules and Peptides

Reprogramming of cells refers to the regression of a specialized cell to a simpler state, resulting in cells with stem-like properties, or the direct transformation of one specialized cell type into another, which is also known as transdifferentiation. The process of cells regressing to a stem cell-like state occurs naturally, mostly for repair and regeneration in aged or damaged tissues, being also known as dedifferentiation. Reprogramming can be artificially induced using a combination of ...

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Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

GMP Version Available: TB1614-GMP
GMP
Chemical Name: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Purity: ≥99%
dopaminergic neurons derived from hiPSCs using SB 431542
(2)
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Highly selective GSK-3 inhibitor; acts as Wnt activator

GMP Version Available: TB4423-GMP
GMP
Alternate Names: CHIR99021,CT99021
Chemical Name: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Purity: ≥98%
Cardiomyocyte derived from human induced pluripotent stem cells (hiPSCs) using CHIR 99021.
(2)
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SB 431542 synthesized to cGMP guidelines

Chemical Name: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Purity: ≥99%
SB 431542 synthesized to cGMP guidelines
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EZH2 histone methyltransferase inhibitor

Alternate Names: DZNep,NSC 617989,HY-12186
Chemical Name: (1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride
Purity: ≥98%
EZH2 histone methyltransferase inhibitor
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CHIR 99021 synthesized to cGMP guidelines

Chemical Name: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Purity: ≥99%
CHIR 99021 synthesized to cGMP guidelines
(2)
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Adenylyl cyclase activator

Alternate Names: Coleonol,Colforsin
Chemical Name: (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
Purity: ≥98%
Adult Stem Cell-derived Liver Organoids
(2)
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Selective inhibitor of TGF-βRI, ALK4 and ALK7

Chemical Name: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Purity: ≥98%
Adult Stem Cell-derived Liver Organoids
(6)
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PORCN inhibitor; inhibits Wnt processing and secretion

Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Purity: ≥98%
iPSC-derived heart organoids differentiated with IWP 2 and CHIR 99021
(2)
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Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Chemical Name: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride
Purity: ≥99%
Prototypical PI 3-kinase inhibitor; also inhibits other kinases
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Potent inhibitor of MEK1/2

Alternate Names: PD325901
Chemical Name: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
Purity: ≥99%
Potent inhibitor of MEK1/2
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Wnt/β-catenin signaling inhibitor; axin stabilizer

Chemical Name: rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
Purity: ≥98%
Wnt/β-catenin signaling inhibitor; axin stabilizer
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Potent tankyrase inhibitor

GMP Version Available: TB3748-GMP
GMP
Alternate Names: XAV939 Wnt Signaling Inhibitor
Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
Purity: ≥98%
Potent tankyrase inhibitor
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p53 inhibitor. Also aryl hydrocarbon receptor agonist

Chemical Name: 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide
p53 inhibitor. Also aryl hydrocarbon receptor agonist
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Potent and selective inhibitor of TGF-βRI

Alternate Names: E-616452,SJN 2511,ALK5 Inhibitor II
Chemical Name: 2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
Purity: ≥99%
Potent and selective inhibitor of TGF-βRI
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Histone deacetylase inhibitor

Alternate Names: VPA,Sodium Valproate
Chemical Name: Sodium 2-propylpentanoate
Histone deacetylase inhibitor
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XAV 939 synthesized to cGMP guidelines

Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
Purity: ≥99%
XAV 939 synthesized to cGMP guidelines
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CK1 inhibitor

Chemical Name: N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride
Purity: ≥99%
CK1 inhibitor
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Retinoic acid analog; RAR agonist

Alternate Names: Ro 13-7410
Chemical Name: 4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid
Purity: ≥98%
Retinoic acid analog; RAR agonist
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Inhibitor of Hedgehog (Hh) signaling

Chemical Name: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol
Purity: ≥97%
Inhibitor of Hedgehog (Hh) signaling
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Potent histone deacetylase inhibitor

Chemical Name: (2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Purity: ≥95%
Potent histone deacetylase inhibitor
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ROCK inhibitor; improves the efficiency of fibroblast reprogramming and induction of iPSCs

Chemical Name: N-Benzyl-[2-(pyrimidin-4-yl)amino]thiazole-4-carboxamide
Purity: ≥98%
ROCK inhibitor ; improves the efficiency of fibroblast reprogramming and induction of iPSCs
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Histone deacetylase inhibitor

Chemical Name: Butanoic acid sodium salt
Histone deacetylase inhibitor
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Irreversible inhibitor of LSD1; also inhibits MAO

Alternate Names: 2-PCPA
Chemical Name: (±)-trans-2-Phenylcyclopropylamine hydrochloride
Purity: ≥98%
Irreversible inhibitor of LSD1; also inhibits MAO
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CaV1.x activator

Chemical Name: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester
Purity: ≥98%
CaV1.x activator
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Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

Chemical Name: N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide
Purity: ≥98%
Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes
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