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21 results for "EGF Receptor Inhibitors" in 产品

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EGF Receptor Inhibitors

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified: EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4).

EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates receptor homo-/heterodimerization and autophosphorylation by the intracellular kinase domain, resulting in receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal rearrangement, decreased apoptosis and increased cell proliferation.

AG 1478 hydrochloride

Catalog #: 1276

(2)

Alternate Names:	Tyrphostin AG 1478
Chemical Name:	N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine hydrochloride
Purity:	≥98%

Alternate Names:	Gefitinib,ZD 1839
Chemical Name:	N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine
Purity:	≥98%

Alternate Names:	Tyrphostin AG 490
Chemical Name:	(E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide
Purity:	≥98%

Chemical Name:	N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
Purity:	≥98%

Chemical Name:	5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Purity:	≥98%

Chemical Name:	1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity:	≥98%

Chemical Name:	N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine
Purity:	≥98%

Chemical Name:	N⁴-(3-Bromophenyl)-N⁶-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine
Purity:	≥98%

Chemical Name:	5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehyde N-(2-morpholin-4-ylethyl) oxime hydrochloride
Purity:	≥97%

Alternate Names:	Mubritinib
Chemical Name:	1-[4-[4-[[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole
Purity:	≥98%

Chemical Name:	6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Purity:	≥98%

Alternate Names:	CI 1033,PD 183805
Chemical Name:	N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride
Purity:	≥98%

Alternate Names:	PF00299804
Chemical Name:	(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide
Purity:	≥98%

Chemical Name:	N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide
Purity:	≥98%

Alternate Names:	BIBW2992
Chemical Name:	(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide dimaleate
Purity:	≥98%

Chemical Name:	(4-Fluorophenyl)methyl N-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-N-[3-[(1-oxo-2-propen-1-yl)amino]phenyl]carbamate
Purity:	≥98%

Chemical Name:	(2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
Purity:	≥98%

Chemical Name:	N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine
Purity:	≥98%

Chemical Name:	N⁶-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N⁴-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine
Purity:	≥98%

Chemical Name:	N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide
Purity:	≥98%

EGF Receptor Inhibitors

AG 1478 hydrochloride

Iressa

AG 490

Erlotinib Hydrochloride

Genistein

PP 3

Lapatinib

GW 583340 dihydrochloride

PD 158780

JNJ 28871063 hydrochloride

TAK 165

AEE 788

Canertinib dihydrochloride

Dacomitinib

WZ 4002

Afatinib dimaleate

JBJ-03-142-02

Neratinib

Vandetanib

Tucatinib

AZD 9291