289 results for "FAK" in 产品
FAK Products
FAK (Focal Adhesion Kinase) is a non-receptor protein tyrosine kinase involved in signal transduction from integrin-enriched focal adhesion sites that mediate cell contact with the extracellular matrix. FAK-enhanced signals have been shown to mediate the survival of anchorage-dependent cells and are critical for efficient cell migration in response to growth factor receptor and integrin stimulation. Elevated expression of FAK in human tumors has been correlated with increased malignancy and invasiveness.
Potent and selective FAK inhibitor
| Chemical Name: | 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone |
| Purity: | ≥98% |
Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 37 different kinases and 2 related total proteins
| Reactivity: | Human |
Selective FAK inhibitor
| Alternate Names: | Y15,NSC 677249 |
| Chemical Name: | 1,2,4,5-Benzenetetramine tetrahydrochloride |
| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #495919 |
| Applications: | KO, IHC, WB, Simple Western |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: FAK [p Tyr397] Antibody [NBP3-12897]](https://resources.rndsystems.com/images/products/FAK-[p-Tyr397]-Antibody-Western-Blot-NBP3-12897-img0001.jpg "Western Blot: FAK [p Tyr397] Antibody [NBP3-12897]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI4D11 |
| Applications: | IHC, WB, Flow, ICC/IF |
![Western Blot: FAK Antibody (OTI4D11)Azide and BSA Free [NBP2-71268]](https://resources.rndsystems.com/images/products/FAK-Antibody-OTI4D11-Azide-and-BSA-Free-Western-Blot-NBP2-71268-img0001.jpg "Western Blot: FAK Antibody (OTI4D11)Azide and BSA Free [NBP2-71268]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #SR46-04 |
| Applications: | IHC, WB, Flow, ICC/IF, IP |
![Western Blot: FAK Antibody (SR46-04) [NBP2-67327]](https://resources.rndsystems.com/images/products/FAK-Antibody-SR46-04-Western-Blot-NBP2-67327-img0012.jpg "Western Blot: FAK Antibody (SR46-04) [NBP2-67327]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Sheep IgG Polyclonal |
| Applications: | KO, IHC, WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI4D11 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: FAK Antibody (OTI4D11) [NBP2-45923]](https://resources.rndsystems.com/images/products/FAK-Antibody-OTI4D11-Western-Blot-NBP2-45923-img0008.jpg "Western Blot: FAK Antibody (OTI4D11) [NBP2-45923]")
| Reactivity: | Human |
| Details: | Rat IgG2A Monoclonal Clone #820755 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
![Western Blot: FAK [p Tyr576] Antibody [NBP3-13071]](https://resources.rndsystems.com/images/products/FAK-[p-Tyr576]-Antibody-Western-Blot-NBP3-13071-img0008.jpg "Western Blot: FAK [p Tyr576] Antibody [NBP3-13071]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ICC/IF |
![Immunohistochemistry-Paraffin: FAK Antibody [NBP1-84750]](https://resources.rndsystems.com/images/products/FAK-Antibody-Immunohistochemistry-Paraffin-NBP1-84750-img0011.jpg "Immunohistochemistry-Paraffin: FAK Antibody [NBP1-84750]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
![Western Blot: FAK [p Tyr407] Antibody [NBP3-13085]](https://resources.rndsystems.com/images/products/FAK-[p-Tyr407]-Antibody-Western-Blot-NBP3-13085-img0005.jpg "Western Blot: FAK [p Tyr407] Antibody [NBP3-13085]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #HL127 |
| Applications: | WB |
| Reactivity: | Human |
| Source: | Sf 9 (baculovirus) |
| Accession #: | NM_153831 |
| Applications: | Bioactivity |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #743101 |
| Applications: | WB |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #SR1077 |
| Applications: | WB, ICC/IF |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 Monoclonal Clone #10H7 |
| Applications: | IHC, WB, ELISA, ICC/IF |
![Western Blot: FAK Antibody (10H7)BSA Free [NBP2-22168]](https://resources.rndsystems.com/images/products/FAK-Antibody-10H7-Western-Blot-NBP2-22168-img0003.jpg "Western Blot: FAK Antibody (10H7)BSA Free [NBP2-22168]")
| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #743234 |
| Applications: | WB |
| Reactivity: | Human |
Dual FAK/PYK2 inhibitor
| Chemical Name: | N-Methyl-N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide |
| Purity: | ≥98% |
Potent FAK inhibitor; orally bioavailable
| Chemical Name: | 2-[[2-[[2-Methoxy-4-(4-morpholinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyridinyl]amino]-N-methylbenzamide |
| Purity: | ≥98% |
Potent and selective FAK and Pyk2 inhibitor
| Chemical Name: | N-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide |
| Purity: | ≥98% |
Highly potent focal adhesion kinase (FAK) Degrader (PROTAC®)
| Chemical Name: | 1-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[[2-[methyl(methylsulfonyl)amino]-3-pyridinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-1H-1,2,3-triazole-4-carboxamide |
| Purity: | ≥98% |
