23 results for "Matrix Metalloprotease (MMP) Inhibitors Small Molecules and Peptides" in 产品
Matrix Metalloprotease (MMP) Inhibitors Small Molecules and Peptides
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules.
24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference:
- Collagenases (MMP-1, -8 and -13)
- Gelatinases (MMP-2 and MMP-9)
- ...
Broad spectrum MMP inhibitor
| Alternate Names: | BB 2516,Marimistat |
| Chemical Name: | (2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide |
| Purity: | ≥98% |
Potent, broad spectrum MMP inhibitor
| Alternate Names: | BB-94 |
| Chemical Name: | (2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide |
| Purity: | ≥98% |
Selective ADAM10 metalloprotease inhibitor
| Chemical Name: | (2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-2-[(1S)-1-(N-hydroxyformamido)ethyl]-5-phenylpentanamide |
| Purity: | ≥98% |
Broad spectrum MMP inhibitor
| Alternate Names: | Galardin,Ilomastat |
| Chemical Name: | (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide |
| Purity: | ≥95% |
Potent MMP inhibitor
| Alternate Names: | SC 78080 |
| Chemical Name: | N-Hydroxy-1-(2-methoxyethyl)-4-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]-4-piperidinecarboxamide hydrochloride |
| Purity: | ≥98% |
Potent ADAM10 and ADAM17 inhibitor
| Chemical Name: | Phenylmethyl N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]carbamate |
| Purity: | ≥98% |
Antibiotic. Displays neuroprotective effects
| Chemical Name: | [4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide |
| Purity: | ≥98% |
Broad-spectrum MMP inhibitor; tetracycline derivative
| Chemical Name: | (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)- 3,5,10,12,12a-pentahydroxy- 6-methyl- 1,11-dioxo- 1,4,4a,5,5a,6,11,12a-octahydrotetracene- 2-carboxamide hydrochloride hemiethanolate hemihydrate |
| Purity: | ≥92% |
Inhibitor of MMP-2
| Chemical Name: | (R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide |
| Purity: | ≥98% |
Histone deacetylase inhibitor
| Chemical Name: | 3,4-Dichloro-N-(1-methylbutyl)benzamide |
| Purity: | ≥98% |
ADAM-17 (TACE) and MMP inhibitor
| Alternate Names: | TNF-α processing inhibitor-0 |
| Chemical Name: | N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide |
| Purity: | ≥95% |
Adam 17 (TACE) and MMP inhibitor; orally bioavailable
| Chemical Name: | (3S)-4-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide |
| Purity: | ≥98% |
ADAM-17 (TACE) and MMP inhibitor
| Chemical Name: | N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide |
| Purity: | ≥95% |
ADAM-17 (TACE) and MMP inhibitor
| Chemical Name: | N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide |
| Purity: | ≥95% |
Pro-MMP9 activation inhibitor
| Chemical Name: | N-[2-[(2-Methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]acetamide |
| Purity: | ≥98% |
Broad spectrum MMP inhibitor
| Chemical Name: | N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine |
| Purity: | ≥98% |
Selective inhibitor of MMP-13
| Chemical Name: | N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide hydrochloride |
| Purity: | ≥98% |
Highly selective MMP-3 and MMP-12 inhibitor
| Chemical Name: | (βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoic acid |
| Purity: | ≥95% |
Potent and selective BMP-1 (PCP) inhibitor
| Chemical Name: | 3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide |
| Purity: | ≥98% |
Potent and selective inhibitor of MMP-13
| Chemical Name: | N-[2-[4-[[[2-[(Hydroxyamino)carbonyl]-4,6-dimethylphenyl](phenylmethyl)amino]sulfonyl]phenoxy]ethyl]-2-benzofurancarboxamide |
| Purity: | ≥98% |
High affinity and selective MMP2 inhibitor
| Chemical Name: | 2-[[(4-Phenoxyphenyl)sulfonyl]methyl]thiirane |
| Purity: | ≥98% |
Potent ADAMTS7 and ADAMTS12 inhibitor
| Chemical Name: | 5,6-Difluoro-N-[[(4S)-4-(1-methyl-1H-pyrazol-5-yl)-2,5-dioxo-4-imidazolidinyl]methyl]-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamide |
| Purity: | ≥98% |
Highly potent and selective MMP-13 inhibitor
| Chemical Name: | 2-Ethyl 5-[3-[[[(4-carboxyphenyl)methyl]amino]carbonyl]-1-methyl-1H-pyrazol-5-yl]-1H-indole-2-carboxylate |
| Purity: | ≥98% |
