8 results for "PAK Inhibitors Small Molecules and Peptides" in 产品
PAK Inhibitors Small Molecules and Peptides
PAK (p21-activated kinases) are a family of serine/threonine kinases within the STE ser/thr protein kinase superfamily that play roles in various oncogenic signaling pathways. Cytoskeletal remodeling, motility, proliferation, and aberrant response to apoptosis and mitosis signals are among oncogenic cell functions coordinated by PAK family members. Group I (PAK1, PAK2 and PAK3, also called alpha, gamma and beta, respectively) contain auto-inhibitory and SH3 domains, in addition to the p21-binding and kinase domains present in Group II (PAK4, PAK6 and PAK7).
Group I PAK inhibitor
| Chemical Name: | 1,1'-Dithiodi-2-naphthtol |
| Purity: | ≥96% |
Potent PAK inhibitor; brain penetrant and orally bioavailable
| Chemical Name: | 6-(2,4-Dichlorophenyl)-8-ethyl-2-[[3-fluoro-4-(1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one |
| Purity: | ≥98% |
Potent group I PAK inhibitor
| Chemical Name: | 6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one |
| Purity: | ≥98% |
High affinity group I PAK inhibitor
| Chemical Name: | 8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one |
| Purity: | ≥98% |
Negative control of NVS PAK1 1 (Cat. No. 6132)
| Chemical Name: | (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N,N-dimethylpyrrolidine-1-carboxamide |
| Purity: | ≥98% |
Potent PAK4 inhibitor; orally available
| Chemical Name: | N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide dihydrochloride |
| Purity: | ≥98% |
Potent and selective PAK1 inhibitor
| Chemical Name: | (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide |
| Purity: | ≥98% |
Highly potent PAK1 and PAK2 inhibitor
| Chemical Name: | 2-[[[2-[[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylphenyl]amino]methyl]benzonitrile |
| Purity: | ≥98% |
