4 results for "Phospholipase C Inhibitors Small Molecules and Peptides" in 产品
Phospholipase C Inhibitors Small Molecules and Peptides
Phospholipase C (PLC) (E.C. 3.1.4.11) represents a group of enzymes that catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions.
There are numerous subtypes of phospholipase C; PLCβ1-4, PLCγ1-2, PLCδ1-4, PLCε1, PLCζ1 and PLCη1-2, all which require Ca2+ ions for catalytic activity. PLC-β is primarily activated by Gq/11 proteins and PLC-γ is activated by tyrosine kinase-mediated phosphorylation in response to a variety of growth factor and immune system signals. PLCε represents a convergence of the 7-TM and receptor tyrosine kinase signaling pathways.
Phospholipase C inhibitor
| Chemical Name: | 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione |
| Purity: | ≥98% |
Analog of U 73122 (Cat. No. 1268)
| Chemical Name: | 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione |
| Purity: | ≥98% |
Selective PC-PLC inhibitor
| Chemical Name: | O-(Octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate |
| Purity: | ≥98% |
Selective PI-PLC inhibitor, also PAF receptor agonist
| Chemical Name: | 4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium 4-oxide |
