VHL/ELOB/ELOC/CUL2/RBX1 Complex Products

Recombinant Human Elongin B/Elongin C/VHL/CUL2/RBX1, CF

Catalog #: E3-655

(1)

Reactivity:	Human
Source:	Sf 21 (baculovirus)
Accession #:	P40337.2, Q15370.1, Q15369.1, Q13617.2, P62877.1
Applications:	Bioactivity

dTAG^V-1

Catalog #: 6914

(2)

Citations (68)

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Potent and selective degrader of mutant FKBP12F36V fusion proteins

Chemical Name:	(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate trifluoroacetate
Purity:	≥98%

dTAG^V-1-NEG

Catalog #: 6915

(1)

Citations (8)

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Negative control for dTAGV-1 (Cat. No. 6914)

Chemical Name:	(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2R,4S)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity:	≥98%

VH 032 amide-alkylC2-amine

Catalog #: 6852

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VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C2-NH₂
Chemical Name:	(2S,4R)-1-((S)-2-(3-Aminopropanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95%

VH 032 amide-alkylC2-acid

Catalog #: 7106

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VHL ligand with alkyl linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C2-COOH
Chemical Name:	4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid
Purity:	≥95%

VH 101 phenol-alkylC4-amine

Catalog #: 7293

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VHL ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name:	(2S,4R)-N-(2-(4-Aminobutoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95%

VH 101 phenol-alkylC6-amine

Catalog #: 7294

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VHL ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name:	(2S,4R)-N-(2-((6-Aminohexyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95%

VH 032 amide-alkylC3-amine

Catalog #: 7073

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VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C3-NH₂
Chemical Name:	(2S,4R)-1-((S)-2-(4-Aminobutanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95%

VH 032 amide-PEG1-acid

Catalog #: 7104

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VHL ligand with PEG linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-PEG1-COOH
Chemical Name:	3-(3-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propanoic acid
Purity:	≥95%

VH 032 amide-PEG5-acid

Catalog #: 7105

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VHL ligand with PEG linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-PEG5-COOH
Chemical Name:	(S)-21-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-22,22-dimethyl-19-oxo-4,7,10,13,16-pentaoxa-20-azatricosanoic acid
Purity:	≥95%

VH 032 amide-PEG2-acid

Catalog #: 7214

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VHL ligand with PEG linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-PEG2-COOH
Chemical Name:	3-(2-(3-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)ethoxy)propanoic acid
Purity:	≥95%

VH 032 amide-alkylC3-acid

Catalog #: 7216

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VHL ligand with alkyl linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C3-COOH
Chemical Name:	5-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-5-oxopentanoic acid
Purity:	≥95%

VH 032 amide-alkylC5-acid

Catalog #: 7217

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VHL ligand with alkyl linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C5-COOH
Chemical Name:	7-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptanoic acid
Purity:	≥95%

VH 032 amide-alkylC9-amine

Catalog #: 7566

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VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C9-NH₂
Chemical Name:	(2S,4R)-1-((S)-2-(10-Aminodecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95%

VH 032 amide-PEG6-amine

Catalog #: 7568

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VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names:	(S,R,S)-AHPC-PEG6-NH₂
Chemical Name:	(2S,4R)-1-((S)-23-Amino-2-(tert-butyl)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95%

VH 298

Catalog #: 6156

Citations (9)

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High-affinity inhibitor of VHL

Chemical Name:	(2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98%

BDY FL VH032

Catalog #: 7483

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High-affinity VHL fluorescent probe for TR-FRET and FP assays

Chemical Name:	(2S,4R)-1-((S)-2-(tert-Butyl)-21-(5,5-difluoro-7,9-dimethyl-5H-5λ⁴,6λ⁴-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)-4,19-dioxo-6,9,12,15-tetraoxa-3,18-diazahenicosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥95%

TBK1 PROTAC^® 3i

Catalog #: 7259

Citations (3)

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Potent TANK-binding kinase 1 (TBK1) PROTAC®

Chemical Name:	(2S,4R)-1-((S)-18-(4-((5-Bromo-4-((3-(N-methylcyclobutanecarboxamido)propyl)amino)pyrimidin-2-yl)amino)phenoxy)-2-(tert-butyl)-4-oxo-6,10,15-trioxa-3-azaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98%

dTAG^V-1 hydrochloride

Catalog #: 7374

(1)

Citations (3)

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Hydrochloride salt of dTAGV-1 (Cat. No. 6914); suitable for in vivo use

Chemical Name:	(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate hydrochloride
Purity:	≥98%

LC 2

Catalog #: 7420

Citations (1)

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Selective KRAS Degrader (PROTAC®)

Chemical Name:	(2S,4R)-1-((S)-2-(3-(3-((S)-2-(((7-(8-Chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥95%

xStAx-VHLL

Catalog #: 7298

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Selective peptide-based β-catenin Degrader (PROTAC®)

Purity:

≥95%

CM 11

Catalog #: 6416

Citations (1)

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Homo-PROTAC® for self-degradation of pVHL30

Chemical Name:	N¹,N²⁰-bis((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide
Purity:	≥98%

CRBN PROTAC^® 14a

Catalog #: 7219

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Cereblon Degrader (PROTAC®)

Chemical Name:	N¹-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N²⁰-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,9,12,18-tetraoxaicosanediamide
Purity:	≥98%

ARV 771

Catalog #: 7256

Citations (1)

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Potent BET bromodomain PROTAC®; also degrades BRD-tagged chimeric antigen receptors (CAR) in T cells

Chemical Name:	(2S,4R)-1-((S)-2-(tert-Butyl)-15-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
Purity:	≥98%

SJF 1521

Catalog #: 7261

Citations (1)

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Selective EGFR PROTAC® Degrader

Chemical Name:	(2S,4R)-1-((S)-2-(tert-Butyl)-14-(4-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)phenoxy)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98%

VHL/ELOB/ELOC/CUL2/RBX1 Complex Products

Recombinant Human Elongin B/Elongin C/VHL/CUL2/RBX1, CF

dTAGV-1

dTAGV-1-NEG

VH 032 amide-alkylC2-amine

VH 032 amide-alkylC2-acid

VH 101 phenol-alkylC4-amine

VH 101 phenol-alkylC6-amine

VH 032 amide-alkylC3-amine

VH 032 amide-PEG1-acid

VH 032 amide-PEG5-acid

VH 032 amide-PEG2-acid

VH 032 amide-alkylC3-acid

VH 032 amide-alkylC5-acid

VH 032 amide-alkylC9-amine

VH 032 amide-PEG6-amine

VH 298

BDY FL VH032

TBK1 PROTAC® 3i

dTAGV-1 hydrochloride

LC 2

xStAx-VHLL

CM 11

CRBN PROTAC® 14a

ARV 771

SJF 1521

dTAG^V-1

dTAG^V-1-NEG

TBK1 PROTAC^® 3i

dTAG^V-1 hydrochloride

CRBN PROTAC^® 14a