Catalog Number: 3280
Chemical Name: 2-Thiouridine 5'-triphosphate tetrasodium salt
Biological Activity
Potent and selective P2Y2 agonist (EC50 values are 0.035, 0.35 and 1.5 μM for hP2Y2, hP2Y4 and hP2Y6 receptors respectively).
Technical Data
  • M.Wt:
    588.13
  • Formula:
    C9H11N2Na4O14P3S
  • Solubility:
    Soluble in water (supplied pre-dissolved at a concentration of 10mM)
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1343364-70-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4 and P2Y6 receptors.
    El-Tayeb et al.
    J.Med.Chem., 2006;49:7076
  2. Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.
    Ko et al.
    Bioorg.Med.Chem., 2008;16:6319
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 2-ThioUTP tetrasodium salt include:

3 Citations: Showing 1 - 3
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  1. Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors.
    Authors: Alkhani Et al.
    Mol Brain 2014;10:43
  2. Silencing of P2Y(2) receptors reduces intraocular pressure in New Zealand rabbits.
    Authors: Martín-Gil Et al.
    Br J Pharmacol 2012;165:1163
  3. Uridine adenosine tetraphosphate-induced contraction is increased in renal but not pulmonary arteries from DOCA-salt hypertensive rats.
    Authors: Matsumoto Et al.
    Am J Physiol Heart Circ Physiol 2011;301:H409

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