Chemical Name: (3β,25R)-Cholest-5-ene-3,26-diol
Biological Activity27-Hydroxycholesterol is a liver X receptor (LXR) agonist. Also estrogen receptor partial agonist. Suppresses β-estradiol-mediated breast cancer cell proliferation in vitro. Also increases α-synuclein levels and induces apoptosis in human neuroblastoma cells in vitro. Endogenous cholesterol metabolite.
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27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells.
Fu et al.
27-hydroxycholesterol is an endogenous selective estrogen receptor modulator
DuSell et al.
Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and α-synuclein in human neuroblastoma SH-SY5Y cells.
Rantham Prabhakara et al.
Citations for 27-Hydroxycholesterol
The citations listed below are publications that use Tocris products. Selected citations for 27-Hydroxycholesterol include:
2 Citations: Showing 1 - 2
The impact of 27-hydroxycholesterol on endometrial cancer proliferation.
Authors: Gibson Et al.
Endocr Relat Cancer 2018;25:381
27-Hydroxycholesterol increases α-synuclein protein levels through proteasomal inhibition in human dopaminergic neurons.
Authors: Schommer Et al.
BMC Neurosci 2018;19:17
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