Chemical Name: (3β,25R)-Cholest-5-ene-3,26-diol
Biological ActivityLiver X receptor (LXR) agonist. Also estrogen receptor partial agonist. Suppresses β-estradiol-mediated breast cancer cell proliferation in vitro. Also increases α-synuclein levels and induces apoptosis in human neuroblastoma cells in vitro. Endogenous cholesterol metabolite.
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Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and α-synuclein in human neuroblastoma SH-SY5Y cells.
Rantham Prabhakara et al.
27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells.
Fu et al.
27-hydroxycholesterol is an endogenous selective estrogen receptor modulator
DuSell et al.
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