27-Hydroxycholesterol

Tocris Bioscience | Catalog # 3907

LXR agonist; also ER partial agonist
Tocris Bioscience

Key Product Details

Description

LXR agonist; also ER partial agonist

Alternative Names

27 OHC,27 HC
View all LXR-like Receptor Agonists »

Product Description

27-Hydroxycholesterol is a liver X receptor (LXR) agonist. Also estrogen receptor partial agonist. Suppresses β-estradiol-mediated breast cancer cell proliferation in vitro. Also increases α-synuclein levels and induces apoptosis in human neuroblastoma cells in vitro. Endogenous cholesterol metabolite.

Product Specifications for 27-Hydroxycholesterol

Molecular Weight

402.65

Formula

C27H46O2

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(3β,25R)-Cholest-5-ene-3,26-diol

CAS Number

20380-11-4

PubChem ID

123976

InChI Key

FYHRJWMENCALJY-YSQMORBQSA-N

SMILES

O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC[C@@H](C)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Ethanol 8.05 20

Preparing Stock Solutions for 27-Hydroxycholesterol

The following data is based on the product molecular weight 402.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.42 mL 62.09 mL 124.18 mL
1 mM 2.48 mL 12.42 mL 24.84 mL
2 mM 1.24 mL 6.21 mL 12.42 mL
10 mM 0.25 mL 1.24 mL 2.48 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for 27-Hydroxycholesterol

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 27-Hydroxycholesterol

For research use only

Citations for 27-Hydroxycholesterol

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