Catalog Number: 3907
Alternate Names: 27 OHC, 27 HC
Chemical Name: (3β,25R)-Cholest-5-ene-3,26-diol
Biological Activity
Liver X receptor (LXR) agonist. Also estrogen receptor partial agonist. Suppresses β-estradiol-mediated breast cancer cell proliferation in vitro. Also increases α-synuclein levels and induces apoptosis in human neuroblastoma cells in vitro. Endogenous cholesterol metabolite.
Technical Data
  • M.Wt:
    402.65
  • Formula:
    C27H46O2
  • Solubility:
    Soluble to 20 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    20380-11-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and α-synuclein in human neuroblastoma SH-SY5Y cells.
    Rantham Prabhakara et al.
    J.Neurochem., 2008;107:1722
  2. 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells.
    Fu et al.
    J.Biol.Chem., 2001;276:38378
  3. 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator
    DuSell et al.
    Mol.Endocrinol., 2008;22:65

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