Catalog Number: 1208
Chemical Name: (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylate
Biological Activity
A highly selective and relatively potent group II metabotropic glutamate receptor agonist. EC50 values are 0.4, 0.4, > 100, > 100, > 300 and > 300 μM for human mGlu2, mGlu3, mGlu1, mGlu5, mGlu4 and mGlu7 receptors respectively. Centrally active following systemic administration in vivo. Also available as part of the Group II mGlu Receptor Tocriset™.
Technical Data
  • M.Wt:
    174.16
  • Formula:
    C6H10N2O4
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    169209-63-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Eli Lilly and Company
Background References
  1. Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase.
    Monn et al.
    J.Med.Chem., 1996;39:2990
  2. Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate.
    Schoepp et al.
    Neuropharmacology, 1995;34:843
  3. Pharmacological agents acting at subtypes of metabotropic glutamate receptors.
    Schoepp et al.
    Neuropharmacology, 1999;38:1431
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (2R,4R)-APDC include:

5 Citations: Showing 1 - 5
Filter your results:

  1. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol 2017;13(4):372
  2. Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats.
    Authors: McIlwrath and Westlund
    Brain Res 2015;21:836
  3. Intrinsic modulators of auditory thalamocortical transmission.
    Authors: Lee and Sherman
    Hear Res 2012;287:43
  4. Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function.
    Authors: Carlton Et al.
    J Neurosci 2009;1248:86
  5. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
    Authors: Proudfoot Et al.
    Curr Biol 2006;16:1591

Have you used (2R,4R)-APDC?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information