Chemical Name: (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylate
Biological Activity(2R,4R)-APDC is a highly selective and relatively potent group II metabotropic glutamate receptor agonist. EC50 values are 0.4, 0.4, > 100, > 100, > 300 and > 300 μM for human mGlu2, mGlu3, mGlu1, mGlu5, mGlu4 and mGlu7 receptors respectively. Centrally active following systemic administration in vivo.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase.
Monn et al.
Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate.
Schoepp et al.
Pharmacological agents acting at subtypes of metabotropic glutamate receptors.
Schoepp et al.
Citations for (2R,4R)-APDC
The citations listed below are publications that use Tocris products. Selected citations for (2R,4R)-APDC include:
8 Citations: Showing 1 - 8
HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
Nat Chem Biol 2017;13(4):372
Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats.
Authors: McIlwrath and Westlund
Brain Res 2015;21:836
A modulatory effect of the feedback from higher visual areas to V1 in the mouse.
Authors: Pasquale and Sherman
J Neurophysiol 2013;109:2618
Intrinsic modulators of auditory thalamocortical transmission.
Authors: Lee and Sherman
Hear Res 2012;287:43
Intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model.
Authors: Ren Et al.
Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function.
Authors: Carlton Et al.
J Neurosci 2009;1248:86
Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism.
Authors: Jiang Et al.
J Neurosci 2006;26:4318
Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
Authors: Proudfoot Et al.
Curr Biol 2006;16:1591
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