Catalog Number: 1208
Chemical Name: (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylate
Biological Activity
A highly selective and relatively potent group II metabotropic glutamate receptor agonist. EC50 values are 0.4, 0.4, > 100, > 100, > 300 and > 300 μM for human mGlu2, mGlu3, mGlu1, mGlu5, mGlu4 and mGlu7 receptors respectively. Centrally active following systemic administration in vivo. Also available as part of the Group II mGlu Receptor Tocriset™.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Eli Lilly and Company
Background References
  1. Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase.
    Monn et al.
    J.Med.Chem., 1996;39:2990
  2. Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate.
    Schoepp et al.
    Neuropharmacology, 1995;34:843
  3. Pharmacological agents acting at subtypes of metabotropic glutamate receptors.
    Schoepp et al.
    Neuropharmacology, 1999;38:1431

The citations listed below are publications that use Tocris products. Selected citations for (2R,4R)-APDC include:

Showing Results 1 - 4 of 4

  1. Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats.
    Authors: McIlwrath and Westlund
    Brain Res
  2. Intrinsic modulators of auditory thalamocortical transmission.
    Authors: Lee and Sherman
    Hear Res
  3. Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function.
    Authors: Carlton Et al.
    J Neurosci
  4. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
    Authors: Proudfoot Et al.
    Curr Biol
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