(2R,4R)-APDC

  ( 7 citations )    
Product Datasheet
Catalog Number:1208
Chemical Name:(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylate
Product Details
Citations (7)
Supplemental Products
Reviews
Biological Activity
A highly selective and relatively potent group II metabotropic glutamate receptor agonist. EC50 values are 0.4, 0.4, > 100, > 100, > 300 and > 300 μM for human mGlu2, mGlu3, mGlu1, mGlu5, mGlu4 and mGlu7 receptors respectively. Centrally active following systemic administration in vivo. Also available as part of the Group II mGlu Receptor Tocriset™.
Technical Data
  • M.Wt:
    174.16
  • Formula:
    C6H10N2O4
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    169209-63-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Eli Lilly and Company
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (2R,4R)-APDC include:

7 Citations: Showing 1 - 7
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  1. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol  2017;13(4):372
  2. Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats.
    Authors: McIlwrath and Westlund
    Brain Res  2015;21:836
  3. A modulatory effect of the feedback from higher visual areas to V1 in the mouse.
    Authors: Pasquale and Sherman
    J Neurophysiol  2013;109:2618
  4. Intrinsic modulators of auditory thalamocortical transmission.
    Authors: Lee and Sherman
    Hear Res  2012;287:43
  5. Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function.
    Authors: Carlton Et al.
    J Neurosci  2009;1248:86
  6. Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism.
    Authors: Jiang Et al.
    J Neurosci  2006;26:4318
  7. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
    Authors: Proudfoot Et al.
    Curr Biol  2006;16:1591

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