2S,6S-Hydroxynorketamine hydrochloride

Catalog # Availability Size / Price Qty
2S,6S-Hydroxynorketamine hydrochloride | CAS No. 1430202-70-2 | AMPA Receptor Agonists
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Description: Decreases D-serine (a NMDA co-agonist); antidepressant

Chemical Name: (2S,6S)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride

Purity: ≥98%

Product Details
Citations (3)

Biological Activity

2S,6S-Hydroxynorketamine hydrochloride is a ketamine metabolite. Decreases intracellular D-serine (a NMDA co-agonist) concentrations in PC-12 cells (IC50 = 0.18 nM). Exerts antidepressant effects in mice.

2R,6R-Enantiomer and Racemate also available.

Technical Data

Soluble to 50 mM in water and to 100 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the NIH, US patent 62/313,309
Other Product-Specific Information:

Product Datasheets

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Citations for 2S,6S-Hydroxynorketamine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for 2S,6S-Hydroxynorketamine hydrochloride include:

3 Citations: Showing 1 - 3


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