Selective agonist of hydroxycarboxylic acid receptor 1 (HCA1
, also known as GPR81) (EC50
M). Inhibits lipolysis in wild-type mouse adipocytes. Displays minimal activity at HCA2
(at concentrations >10 mM) and no activity at HCA3
, free fatty acid receptor (FFAR) 2 or FFAR3.
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3,5-dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes.
Liu et al.