Chemical Name: N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide
Biological Activity(-)-[3R,4S]-Chromanol 293B is a enantiomer that selectively inhibits the slow component of delayed rectifier K+ current (IKs). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC50 values are 1.36 and 9.6 μM respectively). Has negligible inhibitory action at KV11.1 (hERG) channels (IC50 > 30 μM).
Racemate also available.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Molecular impact of MinK on the enantiospecific block of IKs by chromanols.
Lerche et al.
A kinetic study on the stereospecific inhibition of KCNQ1 and IKs by the chromanol 293B.
Seebohm et al.
Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels.
Yang et al.
Citations for (-)-[3R,4S]-Chromanol 293B
The citations listed below are publications that use Tocris products. Selected citations for (-)-[3R,4S]-Chromanol 293B include:
3 Citations: Showing 1 - 3
Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome.
Authors: Song Et al.
The KCNQ1-KCNE2 K+ channel is required for adequate thyroid I- uptake.
Authors: Purtell Et al.
High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents.
Authors: Ma Et al.
FASEB J 2011;301:H2006
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