Chemical Name: N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide
Biological Activity(-)-[3R,4S]-Chromanol 293B is a enantiomer that selectively inhibits the slow component of delayed rectifier K+ current (IKs). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC50 values are 1.36 and 9.6 μM respectively). Has negligible inhibitory action at KV11.1 (hERG) channels (IC50 > 30 μM).
Racemate also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Molecular impact of MinK on the enantiospecific block of IKs by chromanols.
Lerche et al.
A kinetic study on the stereospecific inhibition of KCNQ1 and IKs by the chromanol 293B.
Seebohm et al.
Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels.
Yang et al.
Citations for (-)-[3R,4S]-Chromanol 293B
The citations listed below are publications that use Tocris products. Selected citations for (-)-[3R,4S]-Chromanol 293B include:
3 Citations: Showing 1 - 3
Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome.
Authors: Song Et al.
The KCNQ1-KCNE2 K+ channel is required for adequate thyroid I- uptake.
Authors: Purtell Et al.
High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents.
Authors: Ma Et al.
FASEB J 2011;301:H2006
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Tocris Small Molecules
Reviews for (-)-[3R,4S]-Chromanol 293B
There are currently no reviews for this product. Be the first to review (-)-[3R,4S]-Chromanol 293B and earn rewards!
Have you used (-)-[3R,4S]-Chromanol 293B?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image