Enantiomer that selectively inhibits the slow component of delayed rectifier K+
). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC50
values are 1.36 and 9.6 μ
M respectively). Has negligible inhibitory action at KV
11.1 (hERG) channels (IC50
> 30 μ
M). Racemate Chromanol 293B
(Cat. No. 1412) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Molecular impact of MinK on the enantiospecific block of IKs by chromanols.
Lerche et al.
A kinetic study on the stereospecific inhibition of KCNQ1 and IKs by the chromanol 293B.
Seebohm et al.
Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels.
Yang et al.
The citations listed below are publications that use Tocris products. Selected citations for (-)-[3R,4S]-Chromanol 293B include:
Showing Results 1 - 2 of 2