Catalog Number: 1475
Chemical Name: N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide
Biological Activity
Enantiomer that selectively inhibits the slow component of delayed rectifier K+ current (IKs). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC50 values are 1.36 and 9.6 μM respectively). Has negligible inhibitory action at KV11.1 (hERG) channels (IC50 > 30 μM). Racemate Chromanol 293B (Cat. No. 1412) also available.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in ethanol with gentle warming and to 100 mM in DMSO with gentle warming
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Molecular impact of MinK on the enantiospecific block of IKs by chromanols.
    Lerche et al.
    Br.J.Pharmacol., 2001;131:1503
  2. A kinetic study on the stereospecific inhibition of KCNQ1 and IKs by the chromanol 293B.
    Seebohm et al.
    Br.J.Pharmacol., 2001;134:1647
  3. Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels.
    Yang et al.
    J.Pharmacol.Exp.Ther., 2000;294:955

The citations listed below are publications that use Tocris products. Selected citations for (-)-[3R,4S]-Chromanol 293B include:

Showing Results 1 - 2 of 2

  1. The KCNQ1-KCNE2 K+ channel is required for adequate thyroid I- uptake.
    Authors: Purtell Et al.
  2. High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents.
    Authors: Ma Et al.
Tocris Small Molecules
Description Application Cat# Citations Images  

Chromanol 293B

1412 2  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information