(-)-[3R,4S]-Chromanol 293B

  ( 2 citations )    
Product Datasheet
Catalog Number:1475
Chemical Name:N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide
Product Details
Citations (2)
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Biological Activity
Enantiomer that selectively inhibits the slow component of delayed rectifier K+ current (IKs). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC50 values are 1.36 and 9.6 μM respectively). Has negligible inhibitory action at KV11.1 (hERG) channels (IC50 > 30 μM).

Racemate also available.

Technical Data
  • M.Wt:
    324.39
  • Formula:
    C15H20N2O4S
  • Solubility:
    Soluble to 100 mM in ethanol with gentle warming and to 100 mM in DMSO with gentle warming
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    163163-24-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (-)-[3R,4S]-Chromanol 293B include:

2 Citations: Showing 1 - 2
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  1. The KCNQ1-KCNE2 K+ channel is required for adequate thyroid I- uptake.
    Authors: Purtell Et al.
    Neuropharmacology  2012;26:3252
  2. High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents.
    Authors: Ma Et al.
    FASEB J  2011;301:H2006

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