(-)-[3R,4S]-Chromanol 293B

Tocris Bioscience | Catalog # 1475

IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)
Tocris Bioscience

Key Product Details

Description

IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)
View all Voltage-gated Potassium Channel Blockers »

Product Description

(-)-[3R,4S]-Chromanol 293B is a enantiomer that selectively inhibits the slow component of delayed rectifier K+ current (IKs). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC50 values are 1.36 and 9.6 μM respectively). Has negligible inhibitory action at KV11.1 (hERG) channels (IC50 > 30 μM).

Racemate also available.

Product Specifications for (-)-[3R,4S]-Chromanol 293B

Molecular Weight

324.39

Formula

C15H20N2O4S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide

CAS Number

163163-24-4

PubChem ID

121846

InChI Key

HVSJHHXUORMCGK-UONOGXRCSA-N

SMILES

CCS(=O)(=O)N(C)[C@@H]1[C@@H](O)C(C)(C)OC2=C1C=C(C=C2)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.44 100 with gentle warming
Ethanol 32.44 100 with gentle warming

Preparing Stock Solutions for (-)-[3R,4S]-Chromanol 293B

The following data is based on the product molecular weight 324.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.83 mL
5 mM 0.62 mL 3.08 mL 6.17 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Product Documents for (-)-[3R,4S]-Chromanol 293B

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (-)-[3R,4S]-Chromanol 293B

For research use only

Citations for (-)-[3R,4S]-Chromanol 293B

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