6-Mercaptopurine

Key Product Details

Product Description

6-Mercaptopurine is an inhibitor of de novo purine synthesis through interference with DNA and RNA synthesis. Immunosuppressive and antileukemic drug; reduces the anticoagulation elicited by warfarin. Active metabolite of azathioprine (Cat. No. 4099). Also inhibits SARS-CoV papain-like protease (PL^pro; IC₅₀ = 21.6 μM for PL^pro deubiquitination activity).

Product Specifications for 6-Mercaptopurine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 6-Mercaptopurine

The following data is based on the product molecular weight 152.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.57 mL	32.86 mL	65.71 mL
5 mM	1.31 mL	6.57 mL	13.14 mL
10 mM	0.66 mL	3.29 mL	6.57 mL
50 mM	0.13 mL	0.66 mL	1.31 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Sahasranaman Clinical pharmacology and pharmacogenetics of thiopurines. Eur.J.Clin.Pharmacol. 2008 PMID: 18506437

Product Documents for 6-Mercaptopurine