Chemical Name: Purine-6(1H)-thione
Biological ActivityInhibitor of de novo purine synthesis through interference with DNA and RNA synthesis. Immunosuppressive and antileukemic drug; reduces the anticoagulation elicited by warfarin. Active metabolite of azathioprine (Cat. No. 4099). Also inhibits SARS-CoV papain-like protease (PLpro; IC50 = 21.6 μM for PLpro deubiquitination activity).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Clinical pharmacology and pharmacogenetics of thiopurines.
Sahasranaman et al.
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