Azathioprine

Catalog # Availability Size / Price Qty
4099/50
DNA, RNA and Protein Synthesis Compounds Small Molecule
1 Image
Description: Purine analog; prodrug of 6-mercaptopurine (Cat. No. 4103)

Chemical Name: 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine

Purity: ≥99%

Product Details
Supplemental Products
Reviews (1)

Biological Activity

Purine analog. Blocks DNA replication and the de novo pathway of purine synthesis. Immunosuppressive and anti-inflammatory drug; induces apoptosis in human T-lymphocytes. Prodrug of 6-mercaptopurine (Cat. No. 4103).

Technical Data

M.Wt:
277.26
Formula:
C9H7N7O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
446-86-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Azathioprine: old drug, new actions.
    Maltzman and Koretzky
    J.Clin.Invest., 2003;111:1122

Product Datasheets

Reconstitution Calculator
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Reconstitution Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

⚠ WARNING: This product can expose you to chemicals including Azathioprine, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

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Tocris Small Molecules

6-Mercaptopurine

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Medium concentration of azathioprine slows growth but does not kill melanoma cells in vitro
By Anonymous on 02/14/2019
Species: Human

Azathioprine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.


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