Azathioprine

Tocris Bioscience | Catalog # 4099

Purine analog; prodrug of 6-mercaptopurine (Cat. No. 4103)
Tocris Bioscience
Discontinued Product
4099 has been discontinued. View all DNA, RNA and Protein Synthesis Compounds products.

Key Product Details

Description

Purine analog; prodrug of 6-mercaptopurine (Cat. No. 4103)
View all DNA, RNA and Protein Synthesis Compounds »

Product Description

Azathioprine is a purine analog. Blocks DNA replication and the de novo pathway of purine synthesis. Immunosuppressive and anti-inflammatory drug; induces apoptosis in human T-lymphocytes. Prodrug of 6-mercaptopurine (Cat. No. 4103).

Product Specifications for Azathioprine

Molecular Weight

277.26

Formula

C9H7N7O2S

Storage

Store at -20°C

Purity

≥99% (HPLC)

Chemical Name

6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine

CAS Number

446-86-6

PubChem ID

2265

InChI Key

LMEKQMALGUDUQG-UHFFFAOYSA-N

SMILES

CN1C=NC([N+]([O-])=O)=C1SC2=C3C(N=CN3)=NC=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.73 100

Preparing Stock Solutions for Azathioprine

The following data is based on the product molecular weight 277.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.61 mL 18.03 mL 36.07 mL
5 mM 0.72 mL 3.61 mL 7.21 mL
10 mM 0.36 mL 1.80 mL 3.61 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Azathioprine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Azathioprine

For research use only

⚠ WARNING: This product can expose you to chemicals including Azathioprine, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

Customer Reviews for Azathioprine (1)

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  • Medium concentration of azathioprine slows growth but does not kill melanoma cells in vitro
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 02/14/2019
    Azathioprine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.
    Azathioprine 4099

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