Catalog Number: 1140
Chemical Name: 8-Bromoadenosine-3',5'-cyclic monophosphate sodium salt
Biological Activity
Cell-permeable cAMP analog; activator of protein kinase A. Also available as part of the PKA Tocriset™.
Technical Data
  • M.Wt:
    430.09
  • Formula:
    C10H10BrN5NaO6P
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    76939-46-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells.
    Carranza et al.
    J.Physiol., 1998;511:235
  2. Functional modulation of P2X2 receptors by cyclic AMP-dependent protein kinase.
    Chow et al.
    J.Neurochem., 1998;70:2606
  3. Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs.
    Hei et al.
    Mol.Pharmacol., 1991;39:233
  4. A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells.
    Wang et al.
    Stem Cell Rev., 2011;7:331
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 8-Bromo-cAMP, sodium salt include:

7 Citations: Showing 1 - 7
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  1. GLP-1 acts on habenular avoidance circuits to control nicotine intake.
    Authors: Tuesta
    Nat Neurosci 2017;20(5):708
  2. Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system.
    Authors: Tozzi Et al.
    Front Cell Neurosci 2015;9:192
  3. Astaxanthin protects steroidogenesis from hydrogen peroxide-induced oxidative stress in mouse Leydig cells.
    Authors: Wang Et al.
    J Neurosci 2015;13:1375
  4. GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization.
    Authors: Adelfinger Et al.
    Biochem Pharmacol 2014;91:369
  5. Actin dynamics regulate subcellular localization of PALLD in mouse Sertoli cells.
    Authors: Niedenberger Et al.
    Reproduction 2014;
  6. The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa.
    Authors: Nakao Et al.
    PLoS One 2012;7:e32472
  7. Dopamine-dependent tuning of striatal inhibitory synaptogenesis.
    Authors: Goffin Et al.
    Br J Pharmacol 2010;30:2935

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