8-Bromo-cAMP, sodium salt

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8-Bromo-cAMP, sodium salt | CAS No. 76939-46-3 | cAMP Compounds
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Description: Cell-permeable cAMP analog

Chemical Name: 8-Bromoadenosine-3',5'-cyclic monophosphate sodium salt

Purity: ≥99%

Product Details
Citations (8)
Reviews (1)

Biological Activity

8-Bromo-cAMP, sodium salt is a cell-permeable cyclic AMP (cAMP) analog. It activates PKA and has greater resistance to hydrolysis by phosphodiesterase (PDE) than cAMP. It increases differentiation and induces apoptosis in an esophageal cancer cell line. 8-Bromo-cAMP enhances the induction of pluripotency in human fibroblast cells in combination with VPA (valproic acid) (Cat. No. 2815). In combination with IBMX (Cat. No. 2845), it promotes the differentiation of human iPS cell-derived intestinal epithelial cells. It induces cell-based VEGF production for angiogenesis and osteoblastic differentiation in vitro.

Technical Data

M.Wt:
430.09
Formula:
C10H10BrN5NaO6P
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
76939-46-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype.
    Ylostalo J, Bartosh T, Coble K, Prockop D
    Stem Cells, 2012;30(10):2283-96.
  2. Protein kinase A activation inhibits DUX4 gene expression in myotubes from patients with facioscapulohumeral muscular dystrophy
    JM Cruz, N Hupper, LS Wilson, JB Concannon, Y Wang, B Oberhauser, K Patora-Kom, Y Zhang, DJ Glass, AU Trendelenb, BA Clarke
    J. Biol. Chem., 2018;0(0):.
  3. The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa.
    Nakao T, Tsujikawa M, Notomi S
    PLoS ONE, 2012;7(4):e32472.
  4. Sustained signalling by PTH modulates IP3 accumulation and IP3 receptors through cyclic AMP junctions.
    Meena A, Tovey S, Taylor C
    J Cell Sci, 2015;128(2):408-20.
  5. Functional vascularized lung grafts for lung bioengineering
    NV Dorrello, BA Guenthart, JD O'Neill, J Kim, K Cunningham, YW Chen, M Biscotti, T Swayne, HM Wobma, SXL Huang, HW Snoeck, M Bacchetta, G Vunjak-Nov
    Sci Adv, 2017;3(8):e1700521.
  6. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  7. Phosphorylation of mouse melanopsin by protein kinase a.
    Blasic, Joseph R, Brown, R Lane, Robinson, Phyllis
    PLoS ONE, 2012;7(9):e45387.
  8. Distinct terminal and cell body mechanisms in the nociceptor mediate hyperalgesic priming.
    Ferrari L, Araldi D, Levine J
    J Neurosci, 2015;35(15):6107-16.
  9. A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells.
    Wang et al.
    Stem Cell Rev., 2011;7:331
  10. Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells.
    Carranza et al.
    J.Physiol., 1998;511:235
  11. Functional modulation of P2X2 receptors by cyclic AMP-dependent protein kinase.
    Chow et al.
    J.Neurochem., 1998;70:2606
  12. Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs
    Hei et al.
    Mol.Pharmacol., 1991;39:233
  13. Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs.
    Hei et al.
    Mol.Pharmacol., 1991;39:233
  14. Dual effects of 8-Br-cAMP on differentiation and apoptosis of human esophageal cancer cell line Eca-109.
    Wang et al.
    World J.Gastroenterol., 2005;11:6538
  15. One-day treatment of small molecule 8-bromo-cyclic AMP analogue induces cell-based VEGF production for in vitro angiogenesis and osteoblastic differentiation.
    Lo et al.
    J.Tissue.Eng.Regen. Med., 2016;10:867

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Citations for 8-Bromo-cAMP, sodium salt

The citations listed below are publications that use Tocris products. Selected citations for 8-Bromo-cAMP, sodium salt include:

8 Citations: Showing 1 - 8

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Worked well
By Emma Jones on 01/04/2018

Cells treated in vitro


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