Valproic acid, sodium salt

  ( 3 citations )    
Product Datasheet
Catalog Number:2815
Alternate Names:VPA, Sodium Valproate
Chemical Name:Sodium 2-propylpentanoate
Product Details
Citations (3)
Reviews
Biological Activity
Histone deacetylase inhibitor (IC50 = 400 μM) that exhibits anticancer, anti-inflammatory and neuroprotective effects. Displays anticonvulsive activity via an increase in GABA levels and decreases Aβ production in animal models of Alzheimer's disease. Also attenuates NMDA-mediated excitation, blocks voltage-gated Na+ channels and modulates firing of neurons. Enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2. Can induce autophagy by inhibiting inositol synthesis.
Technical Data
  • M.Wt:
    166.19
  • Formula:
    C8H15NaO2
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Storage:
    Desiccate at RT
  • CAS No:
    1069-66-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Valproic acid, sodium salt include:

3 Citations: Showing 1 - 3
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  1. Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
    Authors: Caires-J?nior
    Nat Commun  2018;9(1):475
  2. Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibition.
    Authors: Chen Et al.
    Nat Commun  2015;35:339
  3. The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer.
    Authors: Wang Et al.
    Cancer Biol Ther  2014;15:1198

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