Valproic acid, sodium salt

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2815/100
Valproic acid, sodium salt | CAS No. 1069-66-5 | Class I Histone Deacetylases Inhibitors
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Description: Histone deacetylase inhibitor
Alternative Names: VPA, Sodium Valproate

Chemical Name: Sodium 2-propylpentanoate

Product Details
Citations (4)
Reviews (2)

Biological Activity

Valproic acid, sodium salt is a histone deacetylase inhibitor (IC50 = 400 μM) that exhibits anticancer, anti-inflammatory and neuroprotective effects. Displays anticonvulsive activity via an increase in GABA levels and decreases Aβ production in animal models of Alzheimer's disease. Also attenuates NMDA-mediated excitation, blocks voltage-gated Na+ channels and modulates firing of neurons. Enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2. Can induce autophagy by inhibiting inositol synthesis. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2.

Technical Data

M.Wt:
166.19
Formula:
C8H15NaO2
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Storage:
Desiccate at RT
CAS No:
1069-66-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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⚠ WARNING: This product can expose you to chemicals including Valproate (Valproic acid), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Valproic acid, sodium salt

The citations listed below are publications that use Tocris products. Selected citations for Valproic acid, sodium salt include:

4 Citations: Showing 1 - 4

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For hPSC culture
By Anonymous on 06/30/2020
Application: Species: Human

Corresponding proteins were seen to play important roles in cellular activity and could influence several important pathways by treat with VPA.


VPA's ability to alter expression of certain genes
By Anonymous on 12/17/2019
Application: Species: Human

We studied VPA's ability to alter expression of certain genes. Corresponding proteins were seen to play important roles in cellular activity and could influence several important pathways such as cell cycle control, differentiation, DNA repair, and apoptosis.


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