Valproic acid, sodium salt
Tocris Bioscience | Catalog # 2815
Key Product Details
Description
Alternative Names
Product Description
Valproic acid, sodium salt is a histone deacetylase inhibitor (IC50 = 400 μM) that exhibits anticancer, anti-inflammatory and neuroprotective effects. Displays anticonvulsive activity via an increase in GABA levels and decreases Aβ production in animal models of Alzheimer's disease. Also attenuates NMDA-mediated excitation, blocks voltage-gated Na+ channels and modulates firing of neurons. Enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2. Can induce autophagy by inhibiting inositol synthesis. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2. Enables generation of Chemically Induced Pluripotent Stem Cells (CiPSCs) from mouse embryonic fibroblasts (see our protocol below).
For more information about how Valproic acid, sodium salt may be used, see our protocol:
Highly Efficient Generation of Chemically Induced Pluripotent Stem Cells (CiPSCs) from Mouse Embryonic Fibroblasts (MEFs).
Product Specifications for Valproic acid, sodium salt
Molecular Weight
Formula
Storage
Chemical Name
CAS Number
PubChem ID
InChI Key
SMILES
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 16.62 | 100 | |
| DMSO | 8.31 | 50 |
Preparing Stock Solutions for Valproic acid, sodium salt
The following data is based on the product molecular weight 166.19.
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.02 mL | 30.09 mL | 60.17 mL |
| 5 mM | 1.20 mL | 6.02 mL | 12.03 mL |
| 10 mM | 0.60 mL | 3.01 mL | 6.02 mL |
| 50 mM | 0.12 mL | 0.60 mL | 1.20 mL |
Calculators
Background References
References are publications that support the biological activity of the product. See our Citations tab to view 23 publications citing the usage of this product.
- Gordon A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature 2020 PMID: 32353859
- Huangfu Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat.Biotechnol. 2008 PMID: 18849973
- Qing Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioural defects in Alzheimer's disease mouse models. J.Exp.Med. 2008 PMID: 18955571
- Kim Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J.Pharmacol.Exp.Ther. 2007 PMID: 17371805
- Kostrouchova Valproic acid, a molecular lead to multiple regulatory pathways. Folia Biologica 2007 PMID: 17448293
- Phiel Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J.Biol.Chem. 2001 PMID: 11473107
Product Documents for Valproic acid, sodium salt
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for Valproic acid, sodium salt
For research use only
⚠ WARNING: This product can expose you to chemicals including Valproate (Valproic acid), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.govCitations for Valproic acid, sodium salt
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Species: HumanAssay Type: In VitroCell Line/Tissue: Human PSCVerified Customer | Posted 06/30/2020Corresponding proteins were seen to play important roles in cellular activity and could influence several important pathways by treat with VPA.
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Species: HumanVerified Customer | Posted 12/17/2019We studied VPA's ability to alter expression of certain genes. Corresponding proteins were seen to play important roles in cellular activity and could influence several important pathways such as cell cycle control, differentiation, DNA repair, and apoptosis.
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