Catalog Number: 2815
Alternate Names: VPA, Sodium Valproate
Chemical Name: Sodium 2-propylpentanoate
Biological Activity
Histone deacetylase inhibitor (IC50 = 400 μM) that exhibits anticancer, anti-inflammatory and neuroprotective effects. Displays anticonvulsive activity via an increase in GABA levels and decreases Aβ production in animal models of Alzheimer's disease. Also attenuates NMDA-mediated excitation, blocks voltage-gated Na+ channels and modulates firing of neurons. Enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2. Can induce autophagy by inhibiting inositol synthesis.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen.
    Phiel et al.
    J.Biol.Chem., 2001;276:36734
  2. Valproic acid, a molecular lead to multiple regulatory pathways.
    Kostrouchova et al.
    Folia Biologica, 2007;53:37
  3. Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action.
    Kim et al.
    J.Pharmacol.Exp.Ther., 2007;321:892
  4. Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioural defects in Alzheimer's disease mouse models.
    Qing et al.
    J.Exp.Med., 2008;205:2781
  5. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.
    Huangfu et al.
    Nat.Biotechnol., 2008;26:1269

The citations listed below are publications that use Tocris products. Selected citations for Valproic acid, sodium salt include:

Showing Results 1 - 2 of 2

  1. Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibition.
    Authors: Chen Et al.
    Nat Commun
  2. The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer.
    Authors: Wang Et al.
    Cancer Biol Ther
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