Valproic acid, sodium salt
Chemical Name: Sodium 2-propylpentanoate
Biological ActivityValproic acid, sodium salt is a histone deacetylase inhibitor (IC50 = 400 μM) that exhibits anticancer, anti-inflammatory and neuroprotective effects. Displays anticonvulsive activity via an increase in GABA levels and decreases Aβ production in animal models of Alzheimer's disease. Also attenuates NMDA-mediated excitation, blocks voltage-gated Na+ channels and modulates firing of neurons. Enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2. Can induce autophagy by inhibiting inositol synthesis. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2.
For more information about how Valproic acid, sodium salt may be used, see our protocol:Highly Efficient Generation of CiPSCs from MEFs
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action.
Kim et al.
Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioural defects in Alzheimer's disease mouse models.
Qing et al.
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen.
Phiel et al.
Valproic acid, a molecular lead to multiple regulatory pathways.
Kostrouchova et al.
Folia Biologica, 2007;53:37
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.
Huangfu et al.
A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing.
Gordon et al.
Citations for Valproic acid, sodium salt
The citations listed below are publications that use Tocris products. Selected citations for Valproic acid, sodium salt include:
4 Citations: Showing 1 - 4
Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
Nat Commun 2018;9(1):475
Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.
Authors: Zeltner Et al.
Nat Med 2016;22:1421
Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibition.
Authors: Chen Et al.
Nat Commun 2015;35:339
The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer.
Authors: Wang Et al.
Cancer Biol Ther 2014;15:1198
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