Chemical Name: 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate acetoxymethyl ester
Biological ActivitySelective Epac activator; cAMP analog. Induces Rap activation and junction tightening in HUVECs; triggers adhesion of Jurkat-Epac1 cells to fibronectin. Stimulates insulin secretion in rat INS-1 cells. More potent, cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645).
This product is a mixture of axial and equatorial isomers. Both isomers give 8CPT-2Me-cAMP after esterase cleavage.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM.
Chepurny et al.
8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue.
Vliem et al.
A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.
Almahariq et al.
Isoform-specific antagonists of exchange proteins directly activated by cAMP.
Tsalkova et al.
Citation for 8-pCPT-2-O-Me-cAMP-AM
The citations listed below are publications that use Tocris products. Selected citations for 8-pCPT-2-O-Me-cAMP-AM include:
1 Citation: Showing 1 - 1
Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
Authors: Watson Et al.
Mol Brain 2015;212:1021
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Tocris Small Molecules
Reviews for 8-pCPT-2-O-Me-cAMP-AM
There are currently no reviews for this product. Be the first to review 8-pCPT-2-O-Me-cAMP-AM and earn rewards!
Have you used 8-pCPT-2-O-Me-cAMP-AM?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image