8-pCPT-2-O-Me-cAMP-AM

Tocris Bioscience | Catalog # 4853

Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645)
Tocris Bioscience

Key Product Details

Description

Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645)

Alternative Names

007-AM
View all EPAC Activators »

Product Description

8-pCPT-2-O-Me-cAMP-AM is a selective Epac activator; cAMP analog. Induces Rap activation and junction tightening in HUVECs; triggers adhesion of Jurkat-Epac1 cells to fibronectin. Stimulates insulin secretion in rat INS-1 cells. More potent, cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645).

This product is a mixture of axial and equatorial isomers. Both isomers give 8CPT-2Me-cAMP after esterase cleavage.

Licensing Information

Sold with the permission of BioLog Life Science Institute.

Product Specifications for 8-pCPT-2-O-Me-cAMP-AM

Molecular Weight

557.90

Formula

C20H21ClN5O8PS

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate acetoxymethyl ester

CAS Number

1152197-23-3

PubChem ID

90488978

InChI Key

FZMWUFYPEVDWPA-SILPBKOMSA-N

SMILES

NC1=NC=NC2=C1N=C(SC4=CC=C(Cl)C=C4)N2[C@@H]3O[C@@](COP(O5)(OCOC(C)=O)=O)([H])[C@]5([H])[C@H]3OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 55.79 100

Preparing Stock Solutions for 8-pCPT-2-O-Me-cAMP-AM

The following data is based on the product molecular weight 557.90.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.79 mL 8.96 mL 17.92 mL
5 mM 0.36 mL 1.79 mL 3.58 mL
10 mM 0.18 mL 0.90 mL 1.79 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 38 publications citing the usage of this product.

Product Documents for 8-pCPT-2-O-Me-cAMP-AM

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 8-pCPT-2-O-Me-cAMP-AM

For research use only

Related Research Areas

Small Monomeric GTPases

Citations for 8-pCPT-2-O-Me-cAMP-AM

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