Home / EPAC Activators / 8-pCPT-2-O-Me-cAMP-AM

8-pCPT-2-O-Me-cAMP-AM

Catalog #: 4853
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4853/100U
8-pCPT-2-O-Me-cAMP-AM | CAS No. 1152197-23-3 | EPAC Activators
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Description: Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645)
Alternative Names: 007-AM

Chemical Name: 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate acetoxymethyl ester

Purity: ≥97%

Product Details
Citations (3)
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Biological Activity

8-pCPT-2-O-Me-cAMP-AM is a selective Epac activator; cAMP analog. Induces Rap activation and junction tightening in HUVECs; triggers adhesion of Jurkat-Epac1 cells to fibronectin. Stimulates insulin secretion in rat INS-1 cells. More potent, cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645).

This product is a mixture of axial and equatorial isomers. Both isomers give 8CPT-2Me-cAMP after esterase cleavage.

Technical Data

M.Wt:
557.9
Formula:
C20H21ClN5O8PS
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
1152197-23-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Complete Your Experiment

8-CPT-2Me-cAMP, sodium salt
Cat # 1645

Additional Information

Licensing Caveats:
Sold with the permission of BioLog Life Science Institute.

Product Datasheets

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Citations for 8-pCPT-2-O-Me-cAMP-AM

The citations listed below are publications that use Tocris products. Selected citations for 8-pCPT-2-O-Me-cAMP-AM include:

3 Citations: Showing 1 - 3

  1. Functional polarization of human hepatoma HepaRG cells in response to forskolin.
    Authors: Mayati Et al.
    Sci Rep  2018;8:1615
  2. Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming TAX Resistance in ER-positive Breast Cancer.
    Authors: Mishra Et al.
    Clin Cancer Res  2018;24:1987
  3. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
    Authors: Watson Et al.
    Mol Brain  2015;212:1021

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8-CPT-2Me-cAMP, sodium salt

1645
11 Citations
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