8-pCPT-2-O-Me-cAMP-AM

Catalog # Availability Size / Price Qty
4853/100U
8-pCPT-2-O-Me-cAMP-AM | CAS No. 1152197-23-3 | EPAC Activators
1 Image
Description: Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645)
Alternative Names: 007-AM

Chemical Name: 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate acetoxymethyl ester

Purity: ≥97%

Product Details
Citations (10)
Supplemental Products
Reviews

Biological Activity

8-pCPT-2-O-Me-cAMP-AM is a selective Epac activator; cAMP analog. Induces Rap activation and junction tightening in HUVECs; triggers adhesion of Jurkat-Epac1 cells to fibronectin. Stimulates insulin secretion in rat INS-1 cells. More potent, cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645).

This product is a mixture of axial and equatorial isomers. Both isomers give 8CPT-2Me-cAMP after esterase cleavage.

Technical Data

M.Wt:
557.9
Formula:
C20H21ClN5O8PS
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
1152197-23-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of BioLog Life Science Institute.

Product Datasheets

Or select another batch:
View Batch
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for 8-pCPT-2-O-Me-cAMP-AM

The citations listed below are publications that use Tocris products. Selected citations for 8-pCPT-2-O-Me-cAMP-AM include:

10 Citations: Showing 1 - 10

  1. Respiratory syncytial virus disrupts the airway epithelial barrier by decreasing cortactin and destabilizing F-actin.
    Authors: Fariba Et al.
    J Cell Sci  2022;135
  2. Regulation of Mitochondrial Function by Epac2 Contributes to Acute Inflammatory Hyperalgesia.
    Authors: Derek C Et al.
    J Neurosci  2021;41:2883-2898
  3. Osmotic Gradients in Epithelial Acini Increase Mechanical Tension across E-cadherin, Drive Morphogenesis, and Maintain Homeostasis.
    Authors: Jason P Et al.
    Curr Biol  2020;30:624-633.e4
  4. Phospho-substrate profiling of Epac-dependent protein kinase C activity.
    Authors: Diana J Et al.
    Mol Cell Biochem  2019;456:167-178
  5. Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype.
    Authors: Caglar Et al.
    J Immunol  2019;203:3247-3255
  6. Functional polarization of human hepatoma HepaRG cells in response to forskolin.
    Authors: Mayati Et al.
    Sci Rep  2018;8:1615
  7. cAMP regulated EPAC1 supports microvascular density, angiogenic and metastatic properties in a model of triple negative breast cancer.
    Authors: Itender Et al.
    Carcinogenesis  2018;39:1245-1253
  8. The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability.
    Authors: Cheng-Mao Et al.
    J Biol Chem  2018;293:717-730
  9. Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming TAX Resistance in ER-positive Breast Cancer.
    Authors: Mishra Et al.
    Clin Cancer Res  2018;24:1987
  10. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
    Authors: Watson Et al.
    Mol Brain  2015;212:1021

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for 8-pCPT-2-O-Me-cAMP-AM

There are currently no reviews for this product. Be the first to review 8-pCPT-2-O-Me-cAMP-AM and earn rewards!

Have you used 8-pCPT-2-O-Me-cAMP-AM?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.