8-pCPT-2-O-Me-cAMP-AM

  ( 1 citations )    
Product Datasheet
Catalog Number:4853
Alternate Names:007-AM
Chemical Name:8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate acetoxymethyl ester
Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity
Selective Epac activator; cAMP analog. Induces Rap activation and junction tightening in HUVECs; triggers adhesion of Jurkat-Epac1 cells to fibronectin. Stimulates insulin secretion in rat INS-1 cells. More potent, cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645).

This product is a mixture of axial and equatorial isomers. Both isomers give 8CPT-2Me-cAMP after esterase cleavage.

Technical Data
  • M.Wt:
    557.9
  • Formula:
    C20H21ClN5O8PS
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >97
  • Storage:
    Store at -80°C
  • CAS No:
    1152197-23-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of BioLog Life Science Institute.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 8-pCPT-2-O-Me-cAMP-AM include:

1 Citations: Showing 1 - 1

  1. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
    Authors: Watson Et al.
    Mol Brain  2015;212:1021

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