Chemical Name: 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate acetoxymethyl ester
Biological ActivitySelective Epac activator; cAMP analog. Induces Rap activation and junction tightening in HUVECs; triggers adhesion of Jurkat-Epac1 cells to fibronectin. Stimulates insulin secretion in rat INS-1 cells. More potent, cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645).
This product is a mixture of axial and equatorial isomers. Both isomers give 8CPT-2Me-cAMP after esterase cleavage.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Enhanced Rap1 activation and Ins secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM.
Chepurny et al.
Isoform-specific antagonists of exchange proteins directly activated by cAMP.
Tsalkova et al.
8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue.
Vliem et al.
A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.
Almahariq et al.
Citations for 8-pCPT-2-O-Me-cAMP-AM
The citations listed below are publications that use Tocris products. Selected citations for 8-pCPT-2-O-Me-cAMP-AM include:
3 Citations: Showing 1 - 3
Functional polarization of human hepatoma HepaRG cells in response to forskolin.
Authors: Mayati Et al.
Sci Rep 2018;8:1615
Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming TAX Resistance in ER-positive Breast Cancer.
Authors: Mishra Et al.
Clin Cancer Res 2018;24:1987
Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
Authors: Watson Et al.
Mol Brain 2015;212:1021
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