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8-pCPT-2-O-Me-cAMP-AM | CAS No. 1152197-23-3 | EPAC Activators
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Description: Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645)
Alternative Names: 007-AM

Chemical Name: 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate acetoxymethyl ester

Purity: ≥97%

Product Details
Citations (10)
Supplemental Products

Biological Activity

8-pCPT-2-O-Me-cAMP-AM is a selective Epac activator; cAMP analog. Induces Rap activation and junction tightening in HUVECs; triggers adhesion of Jurkat-Epac1 cells to fibronectin. Stimulates insulin secretion in rat INS-1 cells. More potent, cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645).

This product is a mixture of axial and equatorial isomers. Both isomers give 8CPT-2Me-cAMP after esterase cleavage.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of BioLog Life Science Institute.

Product Datasheets

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Citations for 8-pCPT-2-O-Me-cAMP-AM

The citations listed below are publications that use Tocris products. Selected citations for 8-pCPT-2-O-Me-cAMP-AM include:

10 Citations: Showing 1 - 10

  1. Respiratory syncytial virus disrupts the airway epithelial barrier by decreasing cortactin and destabilizing F-actin.
    Authors: Fariba Et al.
    J Cell Sci  2022;135
  2. Regulation of Mitochondrial Function by Epac2 Contributes to Acute Inflammatory Hyperalgesia.
    Authors: Derek C Et al.
    J Neurosci  2021;41:2883-2898
  3. Osmotic Gradients in Epithelial Acini Increase Mechanical Tension across E-cadherin, Drive Morphogenesis, and Maintain Homeostasis.
    Authors: Jason P Et al.
    Curr Biol  2020;30:624-633.e4
  4. Phospho-substrate profiling of Epac-dependent protein kinase C activity.
    Authors: Diana J Et al.
    Mol Cell Biochem  2019;456:167-178
  5. Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype.
    Authors: Caglar Et al.
    J Immunol  2019;203:3247-3255
  6. Functional polarization of human hepatoma HepaRG cells in response to forskolin.
    Authors: Mayati Et al.
    Sci Rep  2018;8:1615
  7. cAMP regulated EPAC1 supports microvascular density, angiogenic and metastatic properties in a model of triple negative breast cancer.
    Authors: Itender Et al.
    Carcinogenesis  2018;39:1245-1253
  8. The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability.
    Authors: Cheng-Mao Et al.
    J Biol Chem  2018;293:717-730
  9. Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming TAX Resistance in ER-positive Breast Cancer.
    Authors: Mishra Et al.
    Clin Cancer Res  2018;24:1987
  10. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
    Authors: Watson Et al.
    Mol Brain  2015;212:1021


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