8-CPT-2Me-cAMP, sodium salt
Chemical Name: 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate sodium salt
Biological Activity8-CPT-2Me-cAMP, sodium salt is a selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 > 10 μM). Stimulates Epac-mediated Ca2+-mediated Ca2+ release in pancreatic β-cells in vitro. Cell permeable analog (Cat. No. 4853) also available.
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A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.
Enserink et al.
Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic βcells.
Kang et al.
A family of cAMP-binding proteins that directly activate Rap1.
Kawasaki et al.
Citations for 8-CPT-2Me-cAMP, sodium salt
The citations listed below are publications that use Tocris products. Selected citations for 8-CPT-2Me-cAMP, sodium salt include:
11 Citations: Showing 1 - 10
Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells.
Cell Signal 2018;51:59
Neuroprotective role of prostaglandin PGE2 EP2 receptor in hemin-mediated toxicity.
Authors: Mohan Et al.
Prostacyclin regulates bone growth via the Epac/Rap1 pathway.
Authors: Hutchison and White
PLoS One 2015;156:499
An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer.
Authors: Garcia-Murillas Et al.
Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions.
Authors: Guichard Et al.
Cell Host Microbe 2013;14:294
Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity.
Authors: Hu Et al.
Proc Natl Acad Sci U S A 2012;109:17681
β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
Authors: Meitzen Et al.
J Neurochem 2011;116:984
Isoproterenol and cAMP block ERK phosphorylation and enhance [Ca2+]i increases and oxygen consumption by muscarinic receptor stimulation in rat parotid and submandibular acinar cells.
Authors: Soltoff and Hedden
J Biol Chem 2010;285:13337
Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death.
Authors: Himer Et al.
FASEB J 2010;24:2631
The adenosine a2a receptor inhibits matrix-induced inflammation in a novel fashion.
Authors: Scheibner Et al.
Am J Respir Cell Mol Biol 2009;40:251
IQGAP1 binds Rap1 and modulates its activity.
Authors: Jeong Et al.
J Biol Chem 2007;282:20752
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