Catalog Number: 1645
Chemical Name: 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate sodium salt
Biological Activity
Selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 > 10 μM). Stimulates Epac-mediated Ca2+-mediated Ca2+ release in pancreatic β-cells in vitro. Cell permeable analog (Cat. No. 4853) also available.
Technical Data
  • M.Wt:
    507.82
  • Formula:
    C17H16ClN5O6PS.Na
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    634207-53-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of BioLog Life Science Institute
Background References
  1. A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.
    Enserink et al.
    Nat.Cell.Biol., 2002;4:901
  2. Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic βcells.
    Kang et al.
    J.Biol.Chem., 2003;278:8279
  3. A family of cAMP-binding proteins that directly activate Rap1.
    Kawasaki et al.
    Science, 1998;282:2275
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 8-CPT-2Me-cAMP, sodium salt include:

8 Citations: Showing 1 - 8
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  1. Neuroprotective role of prostaglandin PGE2 EP2 receptor in hemin-mediated toxicity.
    Authors: Mohan Et al.
    Endocrinology 2015;46:53
  2. Prostacyclin regulates bone growth via the Epac/Rap1 pathway.
    Authors: Hutchison and White
    PLoS One 2015;156:499
  3. An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer.
    Authors: Garcia-Murillas Et al.
    Oncogene 2014;33:2478
  4. Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions.
    Authors: Guichard Et al.
    Cell Host Microbe 2013;14:294
  5. Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity.
    Authors: Hu Et al.
    Proc Natl Acad Sci U S A 2012;109:17681
  6. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem 2011;116:984
  7. Isoproterenol and cAMP block ERK phosphorylation and enhance [Ca2+]i increases and oxygen consumption by muscarinic receptor stimulation in rat parotid and submandibular acinar cells.
    Authors: Soltoff and Hedden
    J Biol Chem 2010;285:13337
  8. IQGAP1 binds Rap1 and modulates its activity.
    Authors: Jeong Et al.
    J Biol Chem 2007;282:20752
Tocris Small Molecules
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8-pCPT-2-O-Me-cAMP-AM

4853 1  
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