Selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC50
= 2.2 μ
M), but not PKA (EC50
> 10 μ
M). Stimulates Epac-mediated Ca2+
release in pancreatic β
-cells in vitro
. Cell permeable analog
(Cat. No. 4853) also available.
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A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.
Enserink et al.
Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic βcells.
Kang et al.
A family of cAMP-binding proteins that directly activate Rap1.
Kawasaki et al.
The citations listed below are publications that use Tocris products. Selected citations for 8-CPT-2Me-cAMP, sodium salt include:
Showing Results 1 - 8 of 8