8-CPT-2Me-cAMP, sodium salt

Key Product Details

Product Description

8-CPT-2Me-cAMP, sodium salt is a selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC₅₀ = 2.2 μM), but not PKA (EC₅₀ > 10 μM). Stimulates Epac-mediated Ca²⁺-mediated Ca²⁺ release in pancreatic β-cells in vitro. Cell permeable analog (Cat. No. 4853) also available.

Licensing Information

Sold with the permission of BioLog Life Science Institute

Product Specifications for 8-CPT-2Me-cAMP, sodium salt

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 8-CPT-2Me-cAMP, sodium salt

The following data is based on the product molecular weight 507.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.97 mL	9.85 mL	19.69 mL
5 mM	0.39 mL	1.97 mL	3.94 mL
10 mM	0.20 mL	0.98 mL	1.97 mL
50 mM	0.04 mL	0.20 mL	0.39 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

• Kang Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca²⁺-induced Ca²⁺ release and exocytosis in pancreatic βcells. J.Biol.Chem. 2003 PMID: 12496249
• Kawasaki A family of cAMP-binding proteins that directly activate Rap1. Science 1998 PMID: 9856955
• Enserink A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat.Cell.Biol. 2002 PMID: 12402047

Product Documents for 8-CPT-2Me-cAMP, sodium salt