Catalog Number: 1645
Chemical Name: 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate sodium salt
Biological Activity
Selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 > 10 μM). Stimulates Epac-mediated Ca2+-mediated Ca2+ release in pancreatic β-cells in vitro. Cell permeable analog (Cat. No. 4853) also available.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of BioLog Life Science Institute
Background References
  1. A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.
    Enserink et al.
    Nat.Cell.Biol., 2002;4:901
  2. Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic βcells.
    Kang et al.
    J.Biol.Chem., 2003;278:8279
  3. A family of cAMP-binding proteins that directly activate Rap1.
    Kawasaki et al.
    Science, 1998;282:2275
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