A 740003

  ( 9 citations )    
Product Datasheet
Catalog Number:3701
Chemical Name:N-[1-[[(Cyanoamino)(5-quinolinylamino)methylene]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide
Product Details
Citations (9)
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Reviews
Biological Activity
Potent and selective P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively). Displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μM. Reduces nociception in animal models of persistent neuropathic and inflammatory pain. Also reduces neuroblastoma tumor growth in mice.
Technical Data
  • M.Wt:
    474.55
  • Formula:
    C26H30N6O3
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    861393-28-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for A 740003 include:

9 Citations: Showing 1 - 9
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  1. P2X7Rs are involved in cell death, growth and cellular signaling in primary human osteoblasts
    Authors: Agrawal Et al.
    Bone  2016;95:91
  2. P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages.
    Authors: Englezou Et al.
    Cytokine  2015;74:293
  3. P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2.
    Authors: Adamczyk Et al.
    J.Cell Sci.  2015;128:4615
  4. P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2.
    Authors: Adamczyk Et al.
    Br J Pharmacol  2015;128:4615
  5. Up-regulation of P2X7 receptors mediating proliferation of Schwann cells after sciatic nerve injury.
    Authors: Song Et al.
    J Cell Sci  2015;11:203
  6. Loss of calcium/calmodulin-dependent protein kinase II activity in cortical astrocytes decreases glutamate uptake and induces neurotoxic release of ATP.
    Authors: Ashpole Et al.
    J Biol Chem  2013;288:14599
  7. The P2X7 receptor is a key modulator of aerobic glycolysis.
    Authors: Amoroso Et al.
    Cell Death Dis  2012;3:e370
  8. P2X?-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells.
    Authors: Grol Et al.
    Am J Physiol Endocrinol Metab  2012;302:E561
  9. Purinergic receptors are required for HIV-1 infection of primary human macrophages.
    Authors: Hazleton Et al.
    J Immunol  2012;188:4488

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