A23187, free acid

Catalog # Availability Size / Price Qty
A23187, free acid | CAS No. 52665-69-7 | Calcium Signaling Agents
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Description: Calcium ionophore
Alternative Names: Calcimycin

Chemical Name: 5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid

Purity: ≥98%

Product Details
Citations (11)

Biological Activity

A23187, free acid is a calcium ionophore that induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Promotes intracelllular ROS generation and platelet particle formation (fragmentation) in vitro and in vivo. Can be used to induce autophagy in mammalian cells.

Technical Data

Soluble to 5 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for A23187, free acid

The citations listed below are publications that use Tocris products. Selected citations for A23187, free acid include:

11 Citations: Showing 1 - 10

  1. The mitochondrial ATP synthase is a shared drug target for aging and dementia.
    Authors: Goldberg Et al.
    Aging Cell  2018;17
  2. Bimodal fluorogenic sensing of matrix proteolytic signatures in lung cancer.
    Authors: Megía-Fernández Et al.
    Org Biomol Chem  2018;16:8056
  3. Potential therapeutic action of nitrite in sickle cell disease.
    Authors: Wajih Et al.
    Redox Biol  2017;12:1026
  4. Necrotic pyknosis is a morphologically and biochemically distinct event from apoptotic pyknosis.
    Authors: Hou Et al.
    J Cell Sci  2016;129:3084
  5. Piezo1 links mechanical forces to red blood cell volume.
    Authors: Cahalan Et al.
    Cardiovasc Res  2015;4
  6. Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis.
    Authors: Díaz Et al.
    J Exp Med  2015;212:665
  7. iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis.
    Authors: Schöndorf Et al.
    Nat Commun  2014;5:4028
  8. Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
    Authors: Harper and Poole
    BMC Cancer  2013;4:e969
  9. Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade.
    Authors: Yung Et al.
    Neuropharmacology  2013;13:327
  10. Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice.
    Authors: Cheang Et al.
    Cell Death Dis  2011;92:267


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