Calcium ionophore that induces Ca2+
-dependent cell death by increasing intracellular calcium concentration. Promotes intracelllular ROS generation and platelet particle formation (fragmentation) in vitro
and in vivo
. Can be used to induce autophagy in mammalian cells.
Soluble to 50 mM in DMSO
Desiccate at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Mechanism of A23187-induced apoptosis in HL-60 cells: dependency on mitochondrial permeability transition but not NADPH oxidase.
Kajitani et al.
Platelet particle formation by anti-GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A2, 12-lipoxygenase, and
Nardi et al.
Zn2+, derived from cell preparation, partly attenuates Ca2+-dependent cell death induced by A23187, calcium ionophore, in rat thymocytes.
Sakanashi et al.
Toxicol.In Vitro, 2009;23:338
Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival.
Ding et al.
The citations listed below are publications that use Tocris products. Selected citations for A23187, free acid include:
Showing Results 1 - 6 of 6