A23187, free acid

  ( 8 citations )    
Product Datasheet
Catalog Number:1234
Alternate Names:Calcimycin
Chemical Name:5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R) -3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid
Product Details
Citations (8)
Reviews
Biological Activity
Calcium ionophore that induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Promotes intracelllular ROS generation and platelet particle formation (fragmentation) in vitro and in vivo. Can be used to induce autophagy in mammalian cells.
Technical Data
  • M.Wt:
    523.63
  • Formula:
    C29H37N3O6
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    52665-69-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for A23187, free acid include:

8 Citations: Showing 1 - 8
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  1. Necrotic pyknosis is a morphologically and biochemically distinct event from apoptotic pyknosis.
    Authors: Hou Et al.
    J Cell Sci  2016;129:3084
  2. Piezo1 links mechanical forces to red blood cell volume.
    Authors: Cahalan Et al.
    Cardiovasc Res  2015;4
  3. Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis.
    Authors: Díaz Et al.
    J Exp Med  2015;212:665
  4. iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis.
    Authors: Schöndorf Et al.
    Nat Commun  2014;5:4028
  5. Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
    Authors: Harper and Poole
    BMC Cancer  2013;4:e969
  6. Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade.
    Authors: Yung Et al.
    Neuropharmacology  2013;13:327
  7. Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice.
    Authors: Cheang Et al.
    Cell Death Dis  2011;92:267
  8. Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A.
    Authors: Arozarena Et al.
    Cancer Cell  2011;19:45

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