AACOCF3
Tocris Bioscience | Catalog # 1462
Phospholipase A2 inhibitor
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Key Product Details
Description
Phospholipase A2 inhibitor
Alternative Names
Arachidonyl trifluoromethyl ketone
Product Description
AACOCF3 is a inhibitor of cytosolic (85 kDa) phospholipase A2. Also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro.
Product Specifications for AACOCF3
Molecular Weight
356.47
Formula
C21H31F3O
Storage
Store at -20°C
Chemical Name
1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one
CAS Number
149301-79-1
PubChem ID
5280436
InChI Key
PLWROONZUDKYKG-DOFZRALJSA-N
SMILES
O=C(C(F)(F)F)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Solubility
| Solubility | Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml) |
Calculators
Background References
References are publications that support the biological activity of the product. See our Citations tab to view 33 publications citing the usage of this product.
- Rastogi and McHowat Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium. Respir.Physiol.Neurobiol. 2009 PMID: 19059366
- Riendeau Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. J.Biol.Chem. 1994 PMID: 8195210
- Koutek Inhibitors of arachidonoyl ethanolamide hydrolysis. J.Biol.Chem. 1994 PMID: 8083191
Product Documents for AACOCF3
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for AACOCF3
For research use only
Related Research Areas
Citations for AACOCF3
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Species: MouseAssay Type: In VitroCell Line/Tissue: macrophagesVerified Customer | Posted 10/05/2017Pretreat mouse macrophage cells with this inhibitor prior to the bacterial stimulation.
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