Catalog Number: 1462
Alternate Names: Arachidonyl trifluoromethyl ketone
Chemical Name: 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one
Biological Activity
Inhibitor of cytosolic (85 kDa) phospholipase A2. Also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro.
Technical Data
  • M.Wt:
    356.47
  • Formula:
    C21H31F3O
  • Solubility:
    Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
  • Storage:
    Desiccate at -20°C
  • CAS No:
    149301-79-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibitors of arachidonoyl ethanolamide hydrolysis.
    Koutek et al.
    J.Biol.Chem., 1994;269:22937
  2. Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets.
    Riendeau et al.
    J.Biol.Chem., 1994;269:15619
  3. Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium.
    Rastogi and McHowat
    Respir.Physiol.Neurobiol., 2009;165:167
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AACOCF3 include:

4 Citations: Showing 1 - 4
Filter your results:

  1. The prostaglandin E2-EP3 receptor axis regulates Anaplasma phagocytophilum-mediated NLRC4 inflammasome activation.
    Authors: Wang Et al.
    PLoS Pathog. 2016;12:e1005803
  2. Selective activation of microglia facilitates synaptic strength.
    Authors: Clark Et al.
    Int J Obes (Lond) 2015;35:4552
  3. A novel and essential role for FcγRIIa in cancer cell-induced platelet activation.
    Authors: Mitrugno Et al.
    Blood 2014;123:249
  4. Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia.
    Authors: Bianca Et al.
    Proc Natl Acad Sci U S A 2013;110:15812

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