ABCD1 Antibody

Novus Biologicals | Catalog # NB100-96913

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all ABCD1 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-EDMQRKGYSEQD corresponding to internal region according to NP_000024.2.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Theoretical MW

83 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for ABCD1 Antibody

Western Blot: ABCD1 Antibody [NB100-96913]

Western Blot: ABCD1 Antibody [NB100-96913]

Western Blot: ABCD1 Antibody [NB100-96913] - HEK293 overexpressing human ABCD1 and probed with NB100-96913 at 1ug/ml (mock transfection in first lane).

Applications for ABCD1 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:32000

Western Blot

1:100 - 1:2000
Application Notes
WB: Preliminary experiments gave an approx. 50 kDa band in human brain (cerebellum) lysates after 1 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 82.9 kDa band according to NP_000024.2. The 50 kDa band was successfully blocked by incubation with the immunizing peptide.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: ABCD1

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system. [provided by RefSeq]

Alternate Names

Adrenoleukodystrophy protein, ALDATP-binding cassette sub-family D member 1, ALDPadrenoleukodystrophy, AMNABC42, ATP-binding cassette, sub-family D (ALD), member 1

Entrez Gene IDs

215 (Human)

Gene Symbol

ABCD1

UniProt

P33897 (Human)

Additional ABCD1 Products

Product Documents for ABCD1 Antibody

Certificate of Analysis

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Product Specific Notices for ABCD1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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