Chemical Name: (3β)-17-(3-Pyridinyl)androsta-5,16-dien-3-yl acetate
Biological ActivityPotent CYP17A1 inhibitor (IC50 values are 17 nM and 18 nM for 17,20-lyase activity and 17α-hydroxylase activity, respectively. Inhibits intratumor androgen synthesis in prostate cancer.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Novel steroidal inhibitors of human cytochrome P45017α (l7α-Hydroxylase-Cl7,20-lyase): potential agents for the treatment of prostatic cancer.
Potter et al.
Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase).
Barrie et al.
J.Steroid Biochem.Mol.Biol., 1994;50:267
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