Abiraterone acetate

Tocris Bioscience | Catalog # 6520

Potent CYP17A1 inhibitor
Tocris Bioscience

Key Product Details

Description

Potent CYP17A1 inhibitor
View all Cytochrome P450 Inhibitors »

Product Description

Abiraterone acetate is a potent CYP17A1 inhibitor (IC50 values are 17 nM and 18 nM for 17,20-lyase activity and 17α-hydroxylase activity, respectively). Inhibits intratumor androgen synthesis in prostate cancer.

Product Specifications for Abiraterone acetate

Molecular Weight

391.55

Formula

C26H33NO2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(3β)-17-(3-Pyridinyl)androsta-5,16-dien-3-yl acetate

CAS Number

154229-18-2

PubChem ID

9821849

InChI Key

UVIQSJCZCSLXRZ-UBUQANBQSA-N

SMILES

[H][C@@]12CC=C([C@]1(CC[C@]3([C@]2(CC=C4C[C@@H](OC(C)=O)CC[C@]34C)[H])[H])C)C5=CN=CC=C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.83 20
Ethanol 39.16 100

Preparing Stock Solutions for Abiraterone acetate

The following data is based on the product molecular weight 391.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.77 mL 25.54 mL
5 mM 0.51 mL 2.55 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Abiraterone acetate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Abiraterone acetate

For research use only

⚠ WARNING: This product can expose you to chemicals including Abiraterone acetate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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