AC 187

Catalog # Availability Size / Price Qty
3419/500U
AC 187
1 Image
Description: Potent and selective amylin antagonist
Product Details
Citations (2)
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Biological Activity

Orally active, potent amylin receptor antagonist (IC50 = 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. Increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo.

Technical Data

M.Wt:
2890.25
Formula:
C127H205N37O40
Sequence:
VLGKLSQELHKLQTYPRTNTGSNTY

(Modifications: Val-1 = N-terminal Ac, Tyr-25 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
151804-77-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Antagonist of the amylin receptor blocks β-amyloid toxicity in rat cholinergic basal forebrain neurons.
    Jhamandas and MacTavish
    J.Neurosci., 2004;24:5579
  2. Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187.
    Gedulin et al.
    Regul.Pept., 2006;137:121
  3. Amylin receptor blockade stimulates food intake in rats.
    Reidelberger et al.
    Am.J.Physiol.Inter.Comp.Physiol., 2004;287:R568

Product Datasheets

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Citations for AC 187

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2 Citations: Showing 1 - 2

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