Biological ActivityAC 187 is an orally active, potent amylin receptor antagonist (IC50 = 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. Increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo.
(Modifications: Val-1 = N-terminal Ac, Tyr-25 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Antagonist of the amylin receptor blocks β-amyloid toxicity in rat cholinergic basal forebrain neurons.
Jhamandas and MacTavish
Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187.
Gedulin et al.
Amylin receptor blockade stimulates food intake in rats.
Reidelberger et al.
Citations for AC 187
The citations listed below are publications that use Tocris products. Selected citations for AC 187 include:
2 Citations: Showing 1 - 2
The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats.
Authors: Liberini Et al.
Mol Metab 2016;5:834
Antipsychotic-like actions of the satiety peptide, amylin, in ventral striatal regions marked by overlapping calcitonin receptor and RAMP-1 gene expression.
Authors: Baisley Et al.
J Neurosci 2014;34:4318
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