AC 187

Tocris Bioscience | Catalog # 3419

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Citations (16)

Product Documents

Potent and selective amylin antagonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Potent and selective amylin antagonist

View all Calcitonin and Related Receptor Antagonists »

Product Description

AC 187 is an orally active, potent amylin receptor antagonist (IC₅₀ = 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. Increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo.

Product Specifications for AC 187

Molecular Weight

2890.25

Formula

C₁₂₇H₂₀₅N₃₇O₄₀

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

151804-77-2

PubChem ID

16133792

InChI Key

ZLFXHYNEZYAYPG-AABHONRUSA-N

SMILES

CC(C)C[C@H](NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

Gedulin Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187. Regul.Pept. 2006 PMID: 16914214
Reidelberger Amylin receptor blockade stimulates food intake in rats. Am.J.Physiol.Inter.Comp.Physiol. 2004 PMID: 15130879
Jhamandas and MacTavish Antagonist of the amylin receptor blocks β-amyloid toxicity in rat cholinergic basal forebrain neurons. J.Neurosci. 2004 PMID: 15201330

Product Documents for AC 187

Certificate of Analysis

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Product Specific Notices for AC 187

For research use only

Related Research Areas

Metabolic Peptide Hormones and Regulators

Osteoblast and Osteoclast Markers

Citations for AC 187

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