Catalog Number: 3419
Biological Activity
Orally active, potent amylin receptor antagonist (IC50 = 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. Increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo.
Technical Data
  • M.Wt:
    2890.25
  • Formula:
    C127H205N37O40
  • Sequence:
    VLGKLSQELHKLQTYPRTNTGSNTY

    (Modifications: Val-1 = N-terminal Ac, Tyr-25 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    151804-77-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antagonist of the amylin receptor blocks β-amyloid toxicity in rat cholinergic basal forebrain neurons.
    Jhamandas and MacTavish
    J.Neurosci., 2004;24:5579
  2. Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187.
    Gedulin et al.
    Regul.Pept., 2006;137:121
  3. Amylin receptor blockade stimulates food intake in rats.
    Reidelberger et al.
    Am.J.Physiol.Inter.Comp.Physiol., 2004;287:R568
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AC 187 include:

1 Citations: Showing 1 - 1

  1. Antipsychotic-like actions of the satiety peptide, amylin, in ventral striatal regions marked by overlapping calcitonin receptor and RAMP-1 gene expression.
    Authors: Baisley Et al.
    J Neurosci 2014;34:4318

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