AC 187

  ( 2 citations )    
Product Datasheet
Catalog Number:3419
Chemical Name:
Product Details
Citations (2)
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Biological Activity
Orally active, potent amylin receptor antagonist (IC50 = 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. Increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo.
Technical Data
  • M.Wt:
    2890.25
  • Formula:
    C127H205N37O40
  • Sequence:
    VLGKLSQELHKLQTYPRTNTGSNTY

    (Modifications: Val-1 = N-terminal Ac, Tyr-25 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    151804-77-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for AC 187 include:

2 Citations: Showing 1 - 2
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  1. The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats.
    Authors: Liberini Et al.
    Mol Metab  2016;5:834
  2. Antipsychotic-like actions of the satiety peptide, amylin, in ventral striatal regions marked by overlapping calcitonin receptor and RAMP-1 gene expression.
    Authors: Baisley Et al.
    J Neurosci  2014;34:4318

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