Chemical Name: 4-[4-(2-Butoxyethoxy-)-5-methyl-2-thiazolyl]-2-fluorobenzoic acid
Biological ActivityPotent RARβ2 agonist (pEC50 = 8.1). Selective over RARβ1, RARα and RARγ (pEC50 values are 6.4, 6.2 and 6.3 respectively). More potent and orally available than AC 55649 (Cat. No. 2436).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist.
Lund et al.
Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor β ligands.
Lund et al.
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