Chemical Name: N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide
Biological ActivityPotent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of AC710, a globally selective inhibitor of platelet-derived growth factor receptor-family kinases.
Liu et al.
ACS Med.Chem.Lett., 2012;3:997
Citation for AC 710
The citations listed below are publications that use Tocris products. Selected citations for AC 710 include:
1 Citation: Showing 1 - 1
Substrate stiffness modulates the multipotency of human neural crest derived ectomesenchymalstem cells via CD44 mediated PDGFR signaling.
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