AC 710

Key Product Details

Product Description

AC 710 is a potent PDGFR family inhibitor (IC₅₀ values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; K_d = 1.3 nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.

Product Specifications for AC 710

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AC 710

The following data is based on the product molecular weight 562.70.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	8.89 mL	44.43 mL	88.86 mL
1 mM	1.78 mL	8.89 mL	17.77 mL
2 mM	0.89 mL	4.44 mL	8.89 mL
10 mM	0.18 mL	0.89 mL	1.78 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Liu Discovery of AC710, a globally selective inhibitor of platelet-derived growth factor receptor-family kinases. ACS Med.Chem.Lett. 2012 PMID: 24900421

Product Documents for AC 710