Catalog # Availability Size / Price Qty
ACHP | CAS No. 406208-42-2 | IkB Kinase Inhibitors
1 Image
Description: Selective IKKα and IKKβ inhibitor

Chemical Name: 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile

Purity: ≥97%

Product Details
Citations (12)

Biological Activity

ACHP is a IκB kinase inhibitor (IC50 values are 8.5 and 250 nM for IKKβ and IKKα respectively). Selective for IKKα and IKKβ over IKK3, Syk and MAPKKK4 (IC50 values are > 20 μM). Inhibits DNA binding activity of NF-κB. Blocks NF-κB pathway in multiple myeloma cell lines; induces cell growth arrest and apoptosis. Also inhibits STAT3 signaling in NSCLC in vitro.

Technical Data

Soluble to 20 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for ACHP

The citations listed below are publications that use Tocris products. Selected citations for ACHP include:

12 Citations: Showing 1 - 10

  1. A naturally derived small molecule NDSM253 inhibits IKK1 to suppress inflammation response and promote bone healing after fracture.
    Authors: Lin Et al.
    Am J Transl Res  2021;13:24-37
  2. Histone H3.3 phosphorylation amplifies stimulation-induced transcription.
    Authors: Miao Et al.
    Nature  2020;583:852-857
  3. Patient-specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies.
    Authors: Christoph A Et al.
    Mol Syst Biol  2020;16:e8664
  4. The IκB kinase inhibitor ACHP targets the STAT3 signaling pathway in human non-small cell lung carcinoma cells.
    Authors: Lee Et al.
    Biomolecuces  2019;9:875
  5. Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING.
    Authors: Michael Et al.
    Mol Cell  2019;74:801-815.e6
  6. Dysregulation of Gap Junction Function and Cytokine Production in Response to Non-Genotoxic Polycyclic Aromatic Hydrocarbons in an In Vitro Lung Cell Model.
    Authors: Romo Et al.
    Cancers (Basel)  2019;11
  7. An NFκB-dependent mechanism of tumor cell plasticity and lateral transmission of aggressive features.
    Authors: Espinoza-Sánchez Et al.
    Oncotarget  2018;9:26679
  8. A microfluidics platform for combinatorial drug screening on cancer biopsies.
    Authors: Eduati Et al.
    Nat Commun  2018;9:2434
  9. Cell line with endogenous EGFRvIII expression is a suitable model for research and drug development purposes.
    Authors: Stec Et al.
    Oncotarget  2016;7:31907
  10. Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome.
    Authors: Liu Et al.
    Cell Rep  2016;17:2596


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