B kinase inhibitor (IC50
values are 8.5 and 250 nM for IKKβ
respectively). Selective for IKKα
over IKK3, Syk and MAPKKK4 (IC50
values are > 20 μ
M). Inhibits DNA binding activity of NF-κ
B. Blocks NF-κ
B pathway in multiple myeloma cell lines; induces cell growth arrest and apoptosis.
Soluble to 20 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Growth inhibition of multiple myeloma cells by a novel IκB kinase inhibitor.
Sanda et al.
Clin.Cancer Res., 2005;11:1974
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