ACHP

  ( 4 citations )    
Product Datasheet
Catalog Number:4547
Chemical Name:2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile
Product Details
Citations (4)
Reviews
Biological Activity
IκB kinase inhibitor (IC50 values are 8.5 and 250 nM for IKKβ and IKKα respectively). Selective for IKKα and IKKβ over IKK3, Syk and MAPKKK4 (IC50 values are > 20 μM). Inhibits DNA binding activity of NF-κB. Blocks NF-κB pathway in multiple myeloma cell lines; induces cell growth arrest and apoptosis.
Technical Data
  • M.Wt:
    364.44
  • Formula:
    C21H24N4O2
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >97
  • Storage:
    Store at -20°C
  • CAS No:
    406208-42-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for ACHP include:

4 Citations: Showing 1 - 4
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  1. Cell line with endogenous EGFRvIII expression is a suitable model for research and drug development purposes.
    Authors: Stec Et al.
    Oncotarget  2016;7:31907
  2. Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome.
    Authors: Liu Et al.
    Cell Rep  2016;17:2596
  3. Induction of indoleamine 2, 3-dioxygenase in human dendritic cells by a cholera toxin B subunit-proinsulin vaccine.
    Authors: Mbongue Et al.
    Front Cell Neurosci  2015;10:e0118562
  4. The IκB kinase inhibitor ACHP strongly attenuates TGFβ1-induced myofibroblast formation and collagen synthesis.
    Authors: Mia and Bank
    J Cell Mol Med  2015;

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