Catalog Number: 4547
Chemical Name: 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile
Biological Activity
IκB kinase inhibitor (IC50 values are 8.5 and 250 nM for IKKβ and IKKα respectively). Selective for IKKα and IKKβ over IKK3, Syk and MAPKKK4 (IC50 values are > 20 μM). Inhibits DNA binding activity of NF-κB. Blocks NF-κB pathway in multiple myeloma cell lines; induces cell growth arrest and apoptosis.
Technical Data
  • M.Wt:
    364.44
  • Formula:
    C21H24N4O2
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Store at -20°C
  • CAS No:
    406208-42-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Growth inhibition of multiple myeloma cells by a novel IκB kinase inhibitor.
    Sanda et al.
    Clin.Cancer Res., 2005;11:1974
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ACHP include:

2 Citations: Showing 1 - 2
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  1. Induction of indoleamine 2, 3-dioxygenase in human dendritic cells by a cholera toxin B subunit-proinsulin vaccine.
    Authors: Mbongue Et al.
    Front Cell Neurosci 2015;10:e0118562
  2. The IκB kinase inhibitor ACHP strongly attenuates TGFβ1-induced myofibroblast formation and collagen synthesis.
    Authors: Mia and Bank
    J Cell Mol Med 2015;

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