Chemical Name: 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile
Biological ActivityIκB kinase inhibitor (IC50 values are 8.5 and 250 nM for IKKβ and IKKα respectively). Selective for IKKα and IKKβ over IKK3, Syk and MAPKKK4 (IC50 values are > 20 μM). Inhibits DNA binding activity of NF-κB. Blocks NF-κB pathway in multiple myeloma cell lines; induces cell growth arrest and apoptosis.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Growth inhibition of multiple myeloma cells by a novel IκB kinase inhibitor.
Sanda et al.
Clin.Cancer Res., 2005;11:1974
Synthesis and structure-activity relationships of novel IKK-β inhibitors. Part 3: Orally active anti-inflammatory agents.
Murata et al.
Citations for ACHP
The citations listed below are publications that use Tocris products. Selected citations for ACHP include:
7 Citations: Showing 1 - 7
Dysregulation of Gap Junction Function and Cytokine Production in Response to Non-Genotoxic Polycyclic Aromatic Hydrocarbons in an In Vitro Lung Cell Model.
Authors: Romo Et al.
Cancers (Basel) 2019;11
An NFκB-dependent mechanism of tumor cell plasticity and lateral transmission of aggressive features.
Authors: Espinoza-Sánchez Et al.
A microfluidics platform for combinatorial drug screening on cancer biopsies.
Authors: Eduati Et al.
Nat Commun 2018;9:2434
Cell line with endogenous EGFRvIII expression is a suitable model for research and drug development purposes.
Authors: Stec Et al.
Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome.
Authors: Liu Et al.
Cell Rep 2016;17:2596
Induction of indoleamine 2, 3-dioxygenase in human dendritic cells by a cholera toxin B subunit-proIns vaccine.
Authors: Mbongue Et al.
Front Cell Neurosci 2015;10:e0118562
The IκB kinase inhibitor ACHP strongly attenuates TGFβ1-induced myofibroblast formation and collagen synthesis.
Authors: Mia and Bank
J Cell Mol Med 2015;
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