ADAMTS5 Antibody - BSA Free

Novus Biologicals | Catalog # NLS7761

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bat (100%), Canine (100%), Equine (100%), Hamster (100%), Monkey (100%), Mouse (100%), Primate (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all ADAMTS5 Primary Antibodies »

Product Specifications

Immunogen

Synthetic 18 amino acid peptide from Metalloprotease domain of human ADAMTS5.

Epitope

Metalloprotease domain

Reactivity Notes

For the Primate reactivity listing, there is 100% sequence identity with Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda. Additional percent sequence identity with immunogen and other species is as follows: Bovine (89%), Opossum (89%), Xenopus (89%), and Lizard (83%).

Localization

Secreted. Associated with the extracellular matrix.

Specificity

Human ADAMTS5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for ADAMTS5 Antibody - BSA Free

Immunohistochemistry-Paraffin: ADAMTS5 Antibody - BSA Free [NLS7761]

Immunohistochemistry-Paraffin: ADAMTS5 Antibody - BSA Free [NLS7761]

Immunohistochemistry-Paraffin: ADAMTS5 Antibody [NLS7761] - Colon, Carcinoma
Immunohistochemistry-Paraffin: ADAMTS5 Antibody - BSA Free [NLS7761]

Immunohistochemistry-Paraffin: ADAMTS5 Antibody - BSA Free [NLS7761]

Immunohistochemistry-Paraffin: ADAMTS5 Antibody [NLS7761] - Analysis of anti-ADAMTS5 antibody with cartilage at 3 ug/ ml.
Immunohistochemistry-Paraffin: ADAMTS5 Antibody - BSA Free [NLS7761]

Immunohistochemistry-Paraffin: ADAMTS5 Antibody - BSA Free [NLS7761]

Immunohistochemistry-Paraffin: ADAMTS5 Antibody [NLS7761] - Analysis of anti-ADAMTS5 antibody with human breast, carcinoma.
Immunohistochemistry-Paraffin: ADAMTS5 Antibody - BSA Free [NLS7761]

Immunohistochemistry-Paraffin: ADAMTS5 Antibody - BSA Free [NLS7761]

Immunohistochemistry-Paraffin: ADAMTS5 Antibody [NLS7761] - Human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Immunohistochemistry-Paraffin: ADAMTS5 Antibody - BSA Free [NLS7761]

Immunohistochemistry-Paraffin: ADAMTS5 Antibody - BSA Free [NLS7761]

Immunohistochemistry-Paraffin: ADAMTS5 Antibody [NLS7761] - Anti-ADAMTS5 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Applications for ADAMTS5 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

3 ug/ml
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: ADAMTS5

ADAMTS5, also known as aggrecanase-2, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan. The protein contains a signal sequence, a prodomain with both a potential cysteine switch and a furin cleavage site, a metalloproteinase domain with a conserved zinc-binding motif and a 'met turn,' a disintegrin-like domain, and a spacer region between a thrombospondin type 1 motif and thrombospondin submotif. At least four transcript variants have been reported. ADAMTS5 has been implicated in inflammatory joint diseases. ADAMTS5 expression has been documented in a range of normal human tissues. ESTs have been isolated from human tissue libraries, including normal breast, embryo and heart and cancerous placenta and uterus.

Long Name

A Disintegrin-like and Metalloproteinase Domain with Thrombospondin Motifs 5

Alternate Names

ADAMTS11, ADMP-2, Aggrecanase 2

Entrez Gene IDs

11096 (Human)

Gene Symbol

ADAMTS5

Additional ADAMTS5 Products

Product Documents for ADAMTS5 Antibody - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ADAMTS5 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Metalloproteases and Regulators

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Protocols

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FAQs

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