Chemical Name: N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide
Biological ActivityAICAR is a cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCs in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells.
Wu et al.
5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase.
Giri et al.
Adiponectin and AMP kinase activator stimulate proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells.
Kanazawa et al.
BMC Cell Biol., 2007;8:51
The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: Implication for Krabbe disease.
Giri et al.
Citations for AICAR
The citations listed below are publications that use Tocris products. Selected citations for AICAR include:
20 Citations: Showing 1 - 10
Berberine Attenuated Proliferation, Invasion and Migration by Targeting the AMPK/HNF4α/WNT5A Pathway in Gastric Carcinoma.
Authors: Hu Et al.
Front Pharmacol 2018;9:1150
AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation.
Authors: Marinangeli Et al.
EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis.
Authors: Sen Et al.
Mol Carcinog 2018;57:1342
Direct versus indirect actions of ghrelin on hypothalamic NPY neurons.
PLoS One 2017;12(9):e0184261
Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks.
Authors: Kim Et al.
Mitochondrial complex IV deficiency, caused by mutated COX6B1, is associated with encephalomyopathy, hydrocephalus and cardiomyopathy.
Authors: Abdulhag Et al.
Eur J Hum Genet 2015;23:159
Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.
Authors: Mo Et al.
Nat Cell Biol 2015;17:500
Transcriptomic analysis reveals inhibition of androgen receptor activity by AMPK in prostate cancer cells.
Authors: Jurmeister Et al.
A cell-autonomous molecular cascade initiated by AMP-activated protein kinase represses steroidogenesis.
Authors: Abdou Et al.
Mol Cell Biol 2014;34:4257
Reduced oxidative stress contributes to the lipid lowering effects of isoquercitrin in free fatty acids induced hepatocytes.
Authors: Hassan Et al.
Oxid Med Cell Longev 2014;2014:313602
A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.
Authors: Mohseni Et al.
PLoS One 2014;16:108
Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes.
Authors: Seto Et al.
FASEB J 2013;8:e66404
Calcium release-dependent actin flow in the leading process mediates axophilic migration.
Authors: Hutchins Et al.
J Pharmacol Exp Ther 2013;33:11361
Moderate excess of pyruvate augments osteoclastogenesis.
Authors: Fong Et al.
Biol Open 2013;2:387
Distinct energy requirements for human memory CD4 T-cell homeostatic functions.
Authors: Taub Et al.
BMC Cancer 2013;27:342
AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration.
Authors: Mounier Et al.
Cell Metab 2013;18:251
Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade.
Authors: Yung Et al.
Stem Cells Transl Med 2013;13:327
Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection.
Authors: Terry Et al.
Nat Cell Biol 2012;109:3071
5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated
Authors: Bumpus and Johnson
Proc Natl Acad Sci U S A 2011;339:886
Adenosine monophosphate-activated kinase alpha1 promotes endothelial barrier repair.
Authors: Creighton Et al.
FASEB J 2011;25:3356
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