Catalog # Availability Size / Price Qty
AMPK Activators Small Molecule
1 Image
Description: AMPK activator

Chemical Name: N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide

Purity: ≥99%

Product Details
Citations (17)
Supplemental Products

Biological Activity

Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCs in vitro.

Technical Data

Soluble to 75 mM in water and to 75 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for AICAR

The citations listed below are publications that use Tocris products. Selected citations for AICAR include:

17 Citations: Showing 1 - 10

  1. Direct versus indirect actions of ghrelin on hypothalamic NPY neurons.
    Authors: Hashiguchi
    PLoS One  2017;12(9):e0184261
  2. Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks.
    Authors: Kim Et al.
    EBioMedicine  2016;7:100
  3. Mitochondrial complex IV deficiency, caused by mutated COX6B1, is associated with encephalomyopathy, hydrocephalus and cardiomyopathy.
    Authors: Abdulhag Et al.
    Eur J Hum Genet  2015;23:159
  4. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.
    Authors: Mo Et al.
    Nat Cell Biol  2015;17:500
  5. Transcriptomic analysis reveals inhibition of androgen receptor activity by AMPK in prostate cancer cells.
    Authors: Jurmeister Et al.
    Oncotarget  2014;5:3785
  6. A cell-autonomous molecular cascade initiated by AMP-activated protein kinase represses steroidogenesis.
    Authors: Abdou Et al.
    Mol Cell Biol  2014;34:4257
  7. Reduced oxidative stress contributes to the lipid lowering effects of isoquercitrin in free fatty acids induced hepatocytes.
    Authors: Hassan Et al.
    Oxid Med Cell Longev  2014;2014:313602
  8. A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.
    Authors: Mohseni Et al.
    PLoS One  2014;16:108
  9. Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    FASEB J  2013;8:e66404
  10. Calcium release-dependent actin flow in the leading process mediates axophilic migration.
    Authors: Hutchins Et al.
    J Pharmacol Exp Ther  2013;33:11361


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for AICAR

There are currently no reviews for this product. Be the first to review AICAR and earn rewards!

Have you used AICAR?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.