Chemical Name: N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide
Biological ActivityCell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCs in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells.
Wu et al.
5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase.
Giri et al.
Adiponectin and AMP kinase activator stimulate proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells.
Kanazawa et al.
BMC Cell Biol., 2007;8:51
The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: Implication for Krabbe disease.
Giri et al.
Citations for AICAR
The citations listed below are publications that use Tocris products. Selected citations for AICAR include:
17 Citations: Showing 1 - 10
Direct versus indirect actions of ghrelin on hypothalamic NPY neurons.
PLoS One 2017;12(9):e0184261
Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks.
Authors: Kim Et al.
Mitochondrial complex IV deficiency, caused by mutated COX6B1, is associated with encephalomyopathy, hydrocephalus and cardiomyopathy.
Authors: Abdulhag Et al.
Eur J Hum Genet 2015;23:159
Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.
Authors: Mo Et al.
Nat Cell Biol 2015;17:500
Transcriptomic analysis reveals inhibition of androgen receptor activity by AMPK in prostate cancer cells.
Authors: Jurmeister Et al.
A cell-autonomous molecular cascade initiated by AMP-activated protein kinase represses steroidogenesis.
Authors: Abdou Et al.
Mol Cell Biol 2014;34:4257
Reduced oxidative stress contributes to the lipid lowering effects of isoquercitrin in free fatty acids induced hepatocytes.
Authors: Hassan Et al.
Oxid Med Cell Longev 2014;2014:313602
A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.
Authors: Mohseni Et al.
PLoS One 2014;16:108
Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.
Authors: Seto Et al.
FASEB J 2013;8:e66404
Calcium release-dependent actin flow in the leading process mediates axophilic migration.
Authors: Hutchins Et al.
J Pharmacol Exp Ther 2013;33:11361
Moderate excess of pyruvate augments osteoclastogenesis.
Authors: Fong Et al.
Biol Open 2013;2:387
Distinct energy requirements for human memory CD4 T-cell homeostatic functions.
Authors: Taub Et al.
BMC Cancer 2013;27:342
AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration.
Authors: Mounier Et al.
Cell Metab 2013;18:251
Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade.
Authors: Yung Et al.
Stem Cells Transl Med 2013;13:327
Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection.
Authors: Terry Et al.
Nat Cell Biol 2012;109:3071
5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated
Authors: Bumpus and Johnson
Proc Natl Acad Sci U S A 2011;339:886
Adenosine monophosphate-activated kinase alpha1 promotes endothelial barrier repair.
Authors: Creighton Et al.
FASEB J 2011;25:3356
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