AICAR

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2840/50
AICAR | CAS No. 2627-69-2 | AMPK Activators
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Description: AMPK activator

Chemical Name: N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide

Product Details
Citations (20)
Supplemental Products
Reviews (1)

Biological Activity

Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCs in vitro.

Technical Data

Formula:
C9H14N4O5
Solubility:
Soluble to 75 mM in water and to 75 mM in DMSO
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
2627-69-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for AICAR

The citations listed below are publications that use Tocris products. Selected citations for AICAR include:

20 Citations: Showing 1 - 10

  1. Berberine Attenuated Proliferation, Invasion and Migration by Targeting the AMPK/HNF4α/WNT5A Pathway in Gastric Carcinoma.
    Authors: Hu Et al.
    Front Pharmacol  2018;9:1150
  2. AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation.
    Authors: Marinangeli Et al.
    iScience  2018;9:1
  3. EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis.
    Authors: Sen Et al.
    Mol Carcinog  2018;57:1342
  4. Direct versus indirect actions of ghrelin on hypothalamic NPY neurons.
    Authors: Hashiguchi
    PLoS One  2017;12(9):e0184261
  5. Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks.
    Authors: Kim Et al.
    EBioMedicine  2016;7:100
  6. Mitochondrial complex IV deficiency, caused by mutated COX6B1, is associated with encephalomyopathy, hydrocephalus and cardiomyopathy.
    Authors: Abdulhag Et al.
    Eur J Hum Genet  2015;23:159
  7. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.
    Authors: Mo Et al.
    Nat Cell Biol  2015;17:500
  8. Transcriptomic analysis reveals inhibition of androgen receptor activity by AMPK in prostate cancer cells.
    Authors: Jurmeister Et al.
    Oncotarget  2014;5:3785
  9. A cell-autonomous molecular cascade initiated by AMP-activated protein kinase represses steroidogenesis.
    Authors: Abdou Et al.
    Mol Cell Biol  2014;34:4257
  10. Reduced oxidative stress contributes to the lipid lowering effects of isoquercitrin in free fatty acids induced hepatocytes.
    Authors: Hassan Et al.
    Oxid Med Cell Longev  2014;2014:313602
  11. A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.
    Authors: Mohseni Et al.
    PLoS One  2014;16:108
  12. Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    FASEB J  2013;8:e66404
  13. Calcium release-dependent actin flow in the leading process mediates axophilic migration.
    Authors: Hutchins Et al.
    J Pharmacol Exp Ther  2013;33:11361
  14. Moderate excess of pyruvate augments osteoclastogenesis.
    Authors: Fong Et al.
    Biol Open  2013;2:387
  15. Distinct energy requirements for human memory CD4 T-cell homeostatic functions.
    Authors: Taub Et al.
    BMC Cancer  2013;27:342
  16. AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration.
    Authors: Mounier Et al.
    Cell Metab  2013;18:251
  17. Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade.
    Authors: Yung Et al.
    Stem Cells Transl Med  2013;13:327
  18. Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection.
    Authors: Terry Et al.
    Nat Cell Biol  2012;109:3071
  19. 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated
    Authors: Bumpus and Johnson
    Proc Natl Acad Sci U S A  2011;339:886
  20. Adenosine monophosphate-activated kinase alpha1 promotes endothelial barrier repair.
    Authors: Creighton Et al.
    FASEB J  2011;25:3356

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good product, satisfied
By Kishor Pant on 05/22/2019
Species: Human

Cancer and normal cell lines treated with 2mM for different times and we noticed modulation in the AMPK and p53 expression.


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