AICAR

  ( 14 citations )    
Product Datasheet
Catalog Number:2840
Chemical Name:N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide
Product Details
Citations (14)
Supplemental Products
Reviews
Biological Activity
Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCs in vitro.
Technical Data
  • M.Wt:
    258.23
  • Formula:
    C9H14N4O5
  • Solubility:
    Soluble to 75 mM in water and to 75 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    2627-69-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for AICAR include:

14 Citations: Showing 1 - 10
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  1. Direct versus indirect actions of ghrelin on hypothalamic NPY neurons.
    Authors: Hashiguchi
    PLoS One  2017;12(9):e0184261
  2. Mitochondrial complex IV deficiency, caused by mutated COX6B1, is associated with encephalomyopathy, hydrocephalus and cardiomyopathy.
    Authors: Abdulhag Et al.
    Eur J Hum Genet  2015;23:159
  3. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.
    Authors: Mo Et al.
    Nat Cell Biol  2015;17:500
  4. Transcriptomic analysis reveals inhibition of androgen receptor activity by AMPK in prostate cancer cells.
    Authors: Jurmeister Et al.
    Oncotarget  2014;5:3785
  5. Reduced oxidative stress contributes to the lipid lowering effects of isoquercitrin in free fatty acids induced hepatocytes.
    Authors: Hassan Et al.
    Oxid Med Cell Longev  2014;2014:313602
  6. A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.
    Authors: Mohseni Et al.
    PLoS One  2014;16:108
  7. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    FASEB J  2013;8:e66404
  8. Calcium release-dependent actin flow in the leading process mediates axophilic migration.
    Authors: Hutchins Et al.
    J Pharmacol Exp Ther  2013;33:11361
  9. Moderate excess of pyruvate augments osteoclastogenesis.
    Authors: Fong Et al.
    Biol Open  2013;2:387
  10. Distinct energy requirements for human memory CD4 T-cell homeostatic functions.
    Authors: Taub Et al.
    BMC Cancer  2013;27:342
  11. Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade.
    Authors: Yung Et al.
    Stem Cells Transl Med  2013;13:327
  12. Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection.
    Authors: Terry Et al.
    Nat Cell Biol  2012;109:3071
  13. 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated
    Authors: Bumpus and Johnson
    Proc Natl Acad Sci U S A  2011;339:886
  14. Adenosine monophosphate-activated kinase alpha1 promotes endothelial barrier repair.
    Authors: Creighton Et al.
    FASEB J  2011;25:3356
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