Catalog Number: 2840
Chemical Name: N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide
Biological Activity
Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCs in vitro.
Technical Data
  • M.Wt:
    258.23
  • Formula:
    C9H14N4O5
  • Solubility:
    Soluble to 75 mM in water and to 75 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    2627-69-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase.
    Giri et al.
    J.Neurosci., 2004;24:479
  2. Adiponectin and AMP kinase activator stimulate proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells.
    Kanazawa et al.
    BMC Cell Biol., 2007;8:51
  3. The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: Implication for Krabbe disease.
    Giri et al.
    J.Neurochem., 2008;105:1820
  4. AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells.
    Wu et al.
    Int.J.Artif.Organs., 2011;34:1128
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AICAR include:

11 Citations: Showing 1 - 10
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  1. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.
    Authors: Mo Et al.
    Nat Cell Biol 2015;17:500
  2. Transcriptomic analysis reveals inhibition of androgen receptor activity by AMPK in prostate cancer cells.
    Authors: Jurmeister Et al.
    Oncotarget 2014;5:3785
  3. A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.
    Authors: Mohseni Et al.
    PLoS One 2014;16:108
  4. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    FASEB J 2013;8:e66404
  5. Calcium release-dependent actin flow in the leading process mediates axophilic migration.
    Authors: Hutchins Et al.
    J Pharmacol Exp Ther 2013;33:11361
  6. Moderate excess of pyruvate augments osteoclastogenesis.
    Authors: Fong Et al.
    Biol Open 2013;2:387
  7. Distinct energy requirements for human memory CD4 T-cell homeostatic functions.
    Authors: Taub Et al.
    BMC Cancer 2013;27:342
  8. Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade.
    Authors: Yung Et al.
    Stem Cells Transl Med 2013;13:327
  9. Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection.
    Authors: Terry Et al.
    Nat Cell Biol 2012;109:3071
  10. 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated
    Authors: Bumpus and Johnson
    Proc Natl Acad Sci U S A 2011;339:886
  11. Adenosine monophosphate-activated kinase alpha1 promotes endothelial barrier repair.
    Authors: Creighton Et al.
    FASEB J 2011;25:3356
Expand to show all 11 Citations

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