AICAR

Catalog # Availability Size / Price Qty
2840/50
Cat.No. 2840 - AICAR | C9H14N4O5 | CAS No. 2627-69-2
1 Image
Description: AMPK activator

Chemical Name: N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide

Purity: ≥99%

Product Details
Citations (17)
Supplemental Products
Reviews

Biological Activity

Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCs in vitro.

Technical Data

M.Wt:
258.23
Formula:
C9H14N4O5
Solubility:
Soluble to 75 mM in water and to 75 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
2627-69-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citations for AICAR

The citations listed below are publications that use Tocris products. Selected citations for AICAR include:

17 Citations: Showing 1 - 10

  1. Direct versus indirect actions of ghrelin on hypothalamic NPY neurons.
    Authors: Hashiguchi
    PLoS One  2017;12(9):e0184261
  2. Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks.
    Authors: Kim Et al.
    EBioMedicine  2016;7:100
  3. Mitochondrial complex IV deficiency, caused by mutated COX6B1, is associated with encephalomyopathy, hydrocephalus and cardiomyopathy.
    Authors: Abdulhag Et al.
    Eur J Hum Genet  2015;23:159
  4. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.
    Authors: Mo Et al.
    Nat Cell Biol  2015;17:500
  5. Transcriptomic analysis reveals inhibition of androgen receptor activity by AMPK in prostate cancer cells.
    Authors: Jurmeister Et al.
    Oncotarget  2014;5:3785
  6. A cell-autonomous molecular cascade initiated by AMP-activated protein kinase represses steroidogenesis.
    Authors: Abdou Et al.
    Mol Cell Biol  2014;34:4257
  7. Reduced oxidative stress contributes to the lipid lowering effects of isoquercitrin in free fatty acids induced hepatocytes.
    Authors: Hassan Et al.
    Oxid Med Cell Longev  2014;2014:313602
  8. A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.
    Authors: Mohseni Et al.
    PLoS One  2014;16:108
  9. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    FASEB J  2013;8:e66404
  10. Calcium release-dependent actin flow in the leading process mediates axophilic migration.
    Authors: Hutchins Et al.
    J Pharmacol Exp Ther  2013;33:11361

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