Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCs in vitro
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5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase.
Giri et al.
Adiponectin and AMP kinase activator stimulate proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells.
Kanazawa et al.
BMC Cell Biol., 2007;8:51
The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: Implication for Krabbe disease.
Giri et al.
AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells.
Wu et al.
The citations listed below are publications that use Tocris products. Selected citations for AICAR include:
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