A relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a
), having no effect on group II (mGlu2
) or group III (mGlu4
) receptors expressed individually in baby hamster kidney cells. Has no effect on ionotropic glutamate receptors. Centrally active following systemic administration in vivo
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Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats.
Nielsen et al.
Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist.
Moroni et al.
1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors.
Pellicciari et al.
The citations listed below are publications that use Tocris products. Selected citations for AIDA include:
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