AIDA

  ( 9 citations )    
Product Datasheet
Catalog Number:0904
Alternate Names:UPF 523
Chemical Name:(RS)-1-Aminoindan-1,5-dicarboxylic acid
Product Details
Citations (9)
Supplemental Products
Reviews
Biological Activity
A relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a), having no effect on group II (mGlu2) or group III (mGlu4) receptors expressed individually in baby hamster kidney cells. Has no effect on ionotropic glutamate receptors. Centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
    221.21
  • Formula:
    C11H11NO4
  • Solubility:
    Soluble to 100 mM in 1.1eq. NaOH
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    168560-79-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for AIDA include:

9 Citations: Showing 1 - 9
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  1. Glutamate signals through mGluR2 to control Schwann cell differentiation and proliferation
    Authors: Saitoh Et al.
    Scientific Reports  2016;6:29856
  2. Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors.
    Authors: Mahler Et al.
    Proc Natl Acad Sci U S A  2014;19:49
  3. Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 δ glutamate receptors.
    Authors: Ady Et al.
    J Neurosci  2014;15:103
  4. Cell type-specific regulation of inhibition via cannabinoid type 1 receptors in rat neocortex.
    Authors: De-May and Ali
    J Neurophysiol  2013;109:216
  5. Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals.
    Authors: Cassé Et al.
    J Neurosci  2012;32:5186
  6. Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo.
    Authors: Wibrand Et al.
    Eur J Neurosci  2010;31:636
  7. Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells.
    Authors: Shin Et al.
    EMBO Rep  2008;105:746
  8. Effects of the group I metabotropic glutamate receptor agonist, DHPG, and injection stress on striatal cell signaling in food-restricted and ad libitum fed rats.
    Authors: Pan Et al.
    BMC Neurosci  2004;5:50
  9. Multiple forms of LTP in hippocampal CA3 neurons use a common postsynaptic mechanism.
    Authors: Yeckel Et al.
    Nat Neurosci  1999;2:625

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