ALK/CD246 Antibody (ALK1/6698R)

Novus Biologicals | Catalog # NBP3-49110

Recombinant Monoclonal Antibody
Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Kappa Clone # ALK1/6698R expressed in HEK293
View all ALK/CD246 Primary Antibodies »

Product Specifications

Immunogen

Recombinant human ALK protein fragment around aa 1058-1620 (exact sequence is proprietary) (Uniprot: Q9UM73)

Localization

Cell membrane

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Theoretical MW

177 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Antibody with azide - store at 2 to 8 C. Antibody without azide - store at -20 to -80 C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Scientific Data Images for ALK/CD246 Antibody (ALK1/6698R)

ALK/CD246 Antibody (ALK1/6698R)

Immunohistochemistry-Paraffin: ALK/CD246 Antibody (ALK1/6698R) [NBP3-49110] -

Formalin-fixed, paraffin-embedded human inflammatory myofibroblastic tumor stained with ALK/CD246 Antibody (ALK1/6698R) at 2ug/ml. HIER: Tris/EDTA pH9.0; 95°C/45min. 2�CAb: HRP-Poly:30min. DAB:5min.
ALK/CD246 Antibody (ALK1/6698R)

Immunohistochemistry-Paraffin: ALK/CD246 Antibody (ALK1/6698R) [NBP3-49110] -

Formalin-fixed, paraffin-embedded human Anaplastic Large Cell Lymphoma stained with ALK/CD246 Antibody (ALK1/6698R) at 2ug/ml. HIER: Tris/EDTA pH9.0; 95°C/45min. 2�CAb: HRP-Poly:30min. DAB:5min.
ALK/CD246 Antibody (ALK1/6698R)

Immunohistochemistry-Paraffin: ALK/CD246 Antibody (ALK1/6698R) [NBP3-49110] -

Formalin-fixed, paraffin-embedded human lung adenocarcinoma stained with ALK/CD246 Antibody (ALK1/6698R) at 2ug/ml in PBS. HIER: Tris/EDTA pH9.0; 95°C/45min. 2�CAb: HRP-Poly:30min. DAB:5min.

Applications for ALK/CD246 Antibody (ALK1/6698R)

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: ALK/CD246

ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. The 2;5 chromosomal translocation occurs in most anaplastic large-cell non-Hodgkin's lymphomas arising from activated T lymphocytes. This rearrangement was shown to fuse the NPM nucleolar phosphoprotein gene on chromosome 5q35 to a previously unidentified protein tyrosine kinase gene, ALK, on chromosome 2p23 (1). In the predicted hybrid protein, the amino terminus of NPM is linked to the catalytic domain of ALK. Immunoblotting with anti-ALK antibody shows that ALK is highly expressed in the neonatal brain (2). Also expressed in the small intestine, testis, and brain but not in normal lymphoid cells, ALK shows greatest sequence similarity to the insulin receptor subfamily of kinases. Unscheduled expression of the truncated ALK may contribute to malignant transformation in these lymphomas (3).

Long Name

Anaplastic Lymphoma Kinase

Alternate Names

CD246, Ki-1, Tcrz

Gene Symbol

ALK

Additional ALK/CD246 Products

Product Documents for ALK/CD246 Antibody (ALK1/6698R)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for ALK/CD246 Antibody (ALK1/6698R)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Receptor Tyrosine Kinases (RTKs)

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Protocols

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FAQs

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