Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, CyTOF-ready

Label

Janelia Fluor 669

Antibody Source

Monoclonal Mouse IgG1 Clone # 491613
View all alpha-2B Adrenergic R/ADRA2B Primary Antibodies »

Product Specifications

Immunogen

NS0 mouse myeloma cell line transfected with human alpha ‑2B Adrenergic R/ADRA2B
Accession # P18089

Specificity

Detects human alpha ‑2B Adrenergic R/ADRA2B in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for alpha-2B Adrenergic R/ADRA2B Antibody (491613) [Janelia Fluor® 669]

Application
Recommended Usage

CyTOF-ready

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Spectra Viewer

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

0

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: alpha-2B Adrenergic R/ADRA2B

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences. (provided by RefSeq)

Long Name

Alpha-2B Adrenergic Receptor

Alternate Names

a-2B AdrenergicR, ADRA2B, ADRA2L1, ADRA2RL1, ADRARL1, alpha2B AdrenergicR

Additional alpha-2B Adrenergic R/ADRA2B Products

Product Documents for alpha-2B Adrenergic R/ADRA2B Antibody (491613) [Janelia Fluor® 669]

Certificate of Analysis

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Product Specific Notices for alpha-2B Adrenergic R/ADRA2B Antibody (491613) [Janelia Fluor® 669]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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