Alpha Actinin 2 Antibody (EA-53)

Novus Biologicals | Catalog # NBP1-22630

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # EA-53
View all alpha Actinin 2 Primary Antibodies »

Product Specifications

Immunogen

Purified rabbit skeletal alpha-actinin.

Reactivity Notes

Human.

Localization

Cytoplasmic

Specificity

This antibody is specific for alpha-skeletal muscle and alpha-cardiac actinin. It stains Z lines and dots in stress fibers of myotubes in skeletal and cardiac muscle but not in non-sarcomeric muscle elements. This antibody shows a wide range of cross reactivity with various mammalian species.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Description

Novus Biologicals Mouse Alpha Actinin 2 Antibody (EA-53) (NBP1-22630) is a monoclonal antibody validated for use in IHC. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for Alpha Actinin 2 Antibody (EA-53)

Immunohistochemistry-Paraffin: Alpha Actinin 2 Antibody (EA-53) [NBP1-22630]

Immunohistochemistry-Paraffin: Alpha Actinin 2 Antibody (EA-53) [NBP1-22630]

Immunohistochemistry-Paraffin: Alpha Actinin 2 Antibody (EA-53) [NBP1-22630] - Formalin fixed paraffin embedded human skeletal muscle stained with alpha-Actinin, Sarcomeric antibody (NBP1-22630).
Immunohistochemistry-Paraffin: Alpha Actinin 2 Antibody (EA-53) [NBP1-22630]

Immunohistochemistry-Paraffin: Alpha Actinin 2 Antibody (EA-53) [NBP1-22630]

Immunohistochemistry-Paraffin: Alpha Actinin 2 Antibody (EA-53) [NBP1-22630] - Human skeletal muscle

Applications for Alpha Actinin 2 Antibody (EA-53)

Application
Recommended Usage

Immunohistochemistry

1:20-1:30

Immunohistochemistry-Paraffin

1:20-1:30
Application Notes
IHC-P: recommended pretreatment of EDTA buffer, pH 8.0. Recommended incubation time of 60 min at RT.

Formulation, Preparation, and Storage

Purification

Ascites

Formulation

Ascites

Preservative

0.05% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: alpha Actinin 2

Alpha actinins are actin binding proteins that carry out different purposes in different different cell types. Skeletal, cardiac, and smooth muscle isoforms are localized to the Z disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. ACTN2 encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. There are several known transcript variants that result from the use of multiple polyA+ sites. ACTN2 has the ability to form both homo- and heterodimers (with ACTN3).

Long Name

Actinin alpha 2

Alternate Names

Actinin alpha 2, Actinin-a2, ACTN2, alpha-Actinin 2, Alpha-Actinin Skeletal Muscle, Alpha-Actinin-2, CMD1AA

Entrez Gene IDs

88 (Human)

Gene Symbol

ACTN2

Additional alpha Actinin 2 Products

Product Documents for Alpha Actinin 2 Antibody (EA-53)

Certificate of Analysis

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Product Specific Notices for Alpha Actinin 2 Antibody (EA-53)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for Alpha Actinin 2 Antibody (EA-53)

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Protocols

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